通过酶促动态动力学拆分实现拉米夫定的高效不对称合成。
Efficient asymmetric synthesis of lamivudine via enzymatic dynamic kinetic resolution.
机构信息
Royal Institute of Technology, Department of Chemistry, Teknikringen 30, Stockholm, Sweden.
出版信息
Chem Commun (Camb). 2013 Nov 14;49(88):10376-8. doi: 10.1039/c3cc45551c.
PMID:24071972
Abstract
The anti-HIV nucleoside lamivudine was asymmetrically synthesized in only three steps via a novel surfactant-treated subtilisin Carlsberg-catalyzed dynamic kinetic resolution protocol. The enantiomer of lamivudine could also be accessed using the same protocol catalyzed by Candida antarctica lipase B.
摘要
通过一种新颖的表面活性剂处理的枯草杆菌蛋白酶卡尔逊催化的动态动力学拆分方案，仅三步即可不对称合成抗 HIV 核苷类药物拉米夫定。使用南极假丝酵母脂肪酶 B 催化的相同方案也可以获得拉米夫定的对映异构体。
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