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磁场对寡核苷酸 DNA 的光学特性影响的研究。

Optical characterization of oligonucleotide DNA influenced by magnetic fields.

机构信息

Low Dimensional Materials Research Centre, Department of Physics, University of Malaya, Kuala Lumpur 50603, Malaysia.

出版信息

Molecules. 2013 Sep 25;18(10):11797-808. doi: 10.3390/molecules181011797.

Abstract

UV-VIS spectroscopic analysis of oligonucleotide DNA exposed to different magnetic fields was performed in order to investigate the relationship between DNA extinction coefficients and optical parameters according to magnetic-field strength. The results with the oligonucleotides adenine-thymine 100 mer (AT-100 DNA) and cytosine-guanine 100 mer (CG-100 DNA) indicate that the magnetic field influences DNA molar extinction coefficients and refractive indexes. The imaginary parts of the refractive index and molar extinction coefficients of the AT-100 and CG-100 DNA decreased after exposure to a magnetic field of 750 mT due to cleavage of the DNA oligonucleotides into smaller segments.

摘要

对暴露于不同磁场中的寡核苷酸 DNA 进行了 UV-VIS 光谱分析,以便根据磁场强度研究 DNA 消光系数与光学参数之间的关系。与腺嘌呤-胸腺嘧啶 100 mer(AT-100 DNA)和胞嘧啶-鸟嘌呤 100 mer(CG-100 DNA)的结果表明,磁场会影响 DNA 的摩尔消光系数和折射率。暴露于 750 mT 的磁场后,AT-100 和 CG-100 DNA 的折射率和摩尔消光系数的虚部减小,这是由于 DNA 寡核苷酸被切割成较小的片段。

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