Department of Ophthalmology, Busan Paik Hospital, College of Medicine, Inje University, Busan, South Korea.
Infection. 2014 Feb;42(1):113-8. doi: 10.1007/s15010-013-0530-z. Epub 2013 Sep 26.
To investigate the microorganisms in culture-proven endophthalmitis and their susceptibilities to antimicrobial agents commonly used in South Korea.
Medical records of consecutive patients with culture-proven endophthalmitis at eight institutions between 1 January 2004 and 31 July 31 2010 were reviewed. Four categories of endophthalmitis were studied: postoperative, posttraumatic, endogenous, and unspecified. Outcome measures were culture-proven infectious organisms, antimicrobial susceptibilities, and final visual acuity in the patients.
A total of 93 microorganisms were identified from 103 patients during the study period. The positive culture rate was 59.2 % (103/174). The most common organisms identified were Enterococcus faecalis (in 20.8 % of patients, 20/96), Staphylococcus epidermidis (18.8 %, 18/96), other coagulase-negative staphylococci (10.4 %, 10/96), Pseudomonas aeruginosa (6.3 %, 6/96), and Klebsiella pneumoniae (6.3 %, 6/96). Two cases of Enterococcus faecium (2.1 %) were recognized. Overall, 70 of 96 (73.0 %) isolates were Gram-positive bacteria, 22 (23.0 %) were Gram-negative bacteria, and 4 (4.2 %) were fungi. The most common organisms resulting in reduced light perception were E. faecalis and K. pneumoniae.
The emergence of E. faecalis in endophthalmitis is mainly caused by the high incidence of E. faecalis in postoperative endophthalmitis. This increase also impacts the final visual acuity of the patients.
调查经培养证实的眼内炎中的微生物及其对韩国常用抗菌药物的敏感性。
回顾了 2004 年 1 月 1 日至 2010 年 7 月 31 日期间 8 家机构连续的经培养证实的眼内炎患者的病历。研究了四类眼内炎：术后、外伤性、内源性和未特指。主要观察指标为培养证实的感染病原体、抗菌药物敏感性以及患者的最终视力。
在研究期间，从 103 例患者中共鉴定出 93 种微生物。阳性培养率为 59.2％（103/174）。最常见的病原体为粪肠球菌（20.8％，20/96）、表皮葡萄球菌（18.8％，18/96）、其他凝固酶阴性葡萄球菌（10.4％，10/96）、铜绿假单胞菌（6.3％，6/96）和肺炎克雷伯菌（6.3％，6/96）。还发现了 2 例屎肠球菌（2.1％）。总体而言，96 株分离物中 70 株（73.0％）为革兰阳性菌，22 株（23.0％）为革兰阴性菌，4 株（4.2％）为真菌。导致光感降低的最常见病原体为粪肠球菌和肺炎克雷伯菌。
粪肠球菌在眼内炎中的出现主要是由于术后眼内炎中粪肠球菌的高发，这也影响了患者的最终视力。
