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Maraviroc-induced decrease in circulating bacterial products is not linked to an increase in immune activation in HIV-infected individuals.

作者信息

Psomas Christina, Lavigne Jean-Philippe, Barbuat Claudine, Trabelsi Selma, Ghosn Jade, Lascoux-Combe Caroline, Flandre Philippe, Cuzin Lise, Reynes Jacques, Autran Brigitte, Corbeau Pierre

机构信息

Infectious Diseases Department, University Hospital, Montpellier, Montpellier, France.

出版信息

Blood. 2013 Sep 26;122(13):2282-3. doi: 10.1182/blood-2013-06-507012.

DOI:10.1182/blood-2013-06-507012
PMID:24072848
Abstract
摘要

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2
Response: Maraviroc intensification and microbial translocation.反应:马拉维若强化治疗与微生物易位
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引用本文的文献

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Identification of distinct immune activation profiles in adult humans.鉴定成年人类中不同的免疫激活特征。
Sci Rep. 2020 Nov 30;10(1):20824. doi: 10.1038/s41598-020-77707-6.
2
Microbial Translocation Is Linked to a Specific Immune Activation Profile in HIV-1-Infected Adults With Suppressed Viremia.微生物易位与 HIV-1 感染并病毒血症得到抑制的成年人中特定的免疫激活特征相关联。
Front Immunol. 2019 Sep 13;10:2185. doi: 10.3389/fimmu.2019.02185. eCollection 2019.
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Microbial translocation is correlated with HIV evolution in HIV-HCV co-infected patients.
微生物易位与HIV-HCV合并感染患者的HIV进化相关。
PLoS One. 2017 Sep 21;12(9):e0183372. doi: 10.1371/journal.pone.0183372. eCollection 2017.
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Maraviroc Intensification of cART in Patients with Suboptimal Immunological Recovery: A 48-Week, Placebo-Controlled Randomized Trial.马拉维若强化治疗对免疫恢复欠佳的抗逆转录病毒治疗患者的疗效:一项为期48周的安慰剂对照随机试验。
PLoS One. 2015 Jul 24;10(7):e0132430. doi: 10.1371/journal.pone.0132430. eCollection 2015.
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Treatment intensification with maraviroc (CCR5 antagonist) leads to declines in CD16-expressing monocytes in cART-suppressed chronic HIV-infected subjects and is associated with improvements in neurocognitive test performance: implications for HIV-associated neurocognitive disease (HAND).使用马拉维若(CCR5拮抗剂)强化治疗可使接受cART治疗的慢性HIV感染受试者中表达CD16的单核细胞数量减少,并与神经认知测试表现的改善相关:对HIV相关神经认知疾病(HAND)的意义。
J Neurovirol. 2014 Dec;20(6):571-82. doi: 10.1007/s13365-014-0279-x. Epub 2014 Sep 17.
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Immune responses during spontaneous control of HIV and AIDS: what is the hope for a cure?HIV 和艾滋病自然控制期间的免疫反应:治愈的希望在哪里?
Philos Trans R Soc Lond B Biol Sci. 2014 May 12;369(1645):20130436. doi: 10.1098/rstb.2013.0436. Print 2014.