Institutes of Biology and Medical Sciences, Soochow University, Suzhou, Jiangsu Province, People's Republic of China.
PLoS One. 2013 Sep 20;8(9):e75139. doi: 10.1371/journal.pone.0075139. eCollection 2013.
Resveratrol, a natural polyphenol compound, has broad effects on critical events, including inflammation, oxidation, cancer and aging. However, the function and molecular mechanisms of resveratrol on T cell activation are controversial. In the present study, we found that resveratrol significantly inhibits the activation and cytokine production of T cells in vitro and in vivo. Sirt1 expression was up-regulated in resveratrol-treated T cells. Once Sirt1 was down-regulated in the T cells, the resveratrol-induced inhibition of T cell activation noticeably diminished. The acetylation of c-Jun decreased and its translocation was impeded in the resveratrol-treated T cells. The incidence and severity of collagen-induced arthritis in the resveratrol-treated mice were considerably reduced.
白藜芦醇是一种天然多酚化合物，对包括炎症、氧化、癌症和衰老在内的关键事件具有广泛的影响。然而，白藜芦醇对 T 细胞活化的功能和分子机制存在争议。在本研究中，我们发现白藜芦醇在体外和体内显著抑制 T 细胞的活化和细胞因子的产生。白藜芦醇处理的 T 细胞中 Sirt1 的表达上调。一旦 Sirt1 在 T 细胞中被下调，白藜芦醇诱导的 T 细胞活化抑制作用明显减弱。白藜芦醇处理的 T 细胞中 c-Jun 的乙酰化减少，其易位受阻。白藜芦醇处理的小鼠胶原诱导性关节炎的发生率和严重程度明显降低。
