SOX9 在人类非壶腹十二指肠腺瘤和腺癌中高度表达。
SOX9 Is Highly Expressed in Nonampullary Duodenal Adenoma and Adenocarcinoma in Humans.
机构信息
Division of Gastroenterology, Department of Medicine, Jichi Medical University, Shimotsuke, Japan.
出版信息
Gut Liver. 2013 Sep;7(5):513-8. doi: 10.5009/gnl.2013.7.5.513. Epub 2013 Jun 11.
BACKGROUND/AIMS: SOX9 is a marker for stem cells in the intestine, and overexpression of SOX9 is found in gastric and colon cancer; however, the expression of SOX9 in nonampullary duodenal adenoma and adenocarcinoma has not yet been evaluated. This study aimed to investigate SOX9 expression in nonampullary duodenal adenoma and adenocarcinoma by immunohistochemistry.
METHODS
We evaluated SOX9 expression in 43 clinical samples (nonampullary duodenal adenoma in 22 lesions and nonampullary duodenal adenocarcinoma in 21 lesions) resected under endoscopic mucosal resection or endoscopic submucosal dissection.
RESULTS
SOX9 was expressed in part of the base of the normal duodenal mucosa surrounding adenomas and adenocarcinomas. In contrast, SOX9-positive cells were found in more than half of the crypts from the bottom part of the crypt in all of the 43 samples. Moreover, in 15 adenoma samples (68.2%) and 19 carcinoma samples (90.5%), SOX9 was expressed in more than three-quarters of the crypts from the bottom part of the crypt.
CONCLUSIONS
SOX9 is overexpressed in nonampullary duodenal adenoma and adenocarcinoma in humans.
背景/目的：SOX9 是肠道干细胞的标志物，其在胃癌和结肠癌中过表达；然而，SOX9 在非壶腹十二指肠腺瘤和腺癌中的表达尚未得到评估。本研究旨在通过免疫组织化学方法检测非壶腹十二指肠腺瘤和腺癌中 SOX9 的表达。
方法
我们评估了 43 例临床样本（22 例非壶腹十二指肠腺瘤和 21 例非壶腹十二指肠腺癌）中 SOX9 的表达，这些样本均通过内镜黏膜切除术或内镜黏膜下剥离术切除。
结果
SOX9 在腺瘤和腺癌周围正常十二指肠黏膜的基底部分表达。相比之下，在所有 43 例样本中，从隐窝底部的隐窝中发现超过一半的隐窝存在 SOX9 阳性细胞。此外，在 15 例腺瘤样本（68.2%）和 19 例癌样本（90.5%）中，SOX9 在隐窝底部超过四分之三的隐窝中表达。
结论
SOX9 在人类非壶腹十二指肠腺瘤和腺癌中过表达。
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