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Alzheimer's disease--neuropathological aspects.

作者信息

Bergeron C

机构信息

Department of Pathology (Neuropathology), University of Toronto, Ontario.

出版信息

Can J Vet Res. 1990 Jan;54(1):58-64.

PMID:2407331
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1255607/
Abstract

Alzheimer's disease is characterized neuropathologically by the progressive atrophy and death of selected neuronal populations. Prominent cytoskeletal changes are also observed, as well as the formation of neuritic plaques associated with the abnormal deposition of amyloid in the brain. The nature, pathogenesis and distribution of these changes are discussed.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23dd/1255607/45c1c505beeb/cjvetres00045-0063-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23dd/1255607/802d20e9e265/cjvetres00045-0061-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23dd/1255607/71c491dc0ad9/cjvetres00045-0061-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23dd/1255607/d5f6d2e0b397/cjvetres00045-0062-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23dd/1255607/9a4052de7f75/cjvetres00045-0062-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23dd/1255607/45c1c505beeb/cjvetres00045-0063-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23dd/1255607/802d20e9e265/cjvetres00045-0061-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23dd/1255607/71c491dc0ad9/cjvetres00045-0061-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23dd/1255607/d5f6d2e0b397/cjvetres00045-0062-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23dd/1255607/9a4052de7f75/cjvetres00045-0062-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23dd/1255607/45c1c505beeb/cjvetres00045-0063-a.jpg

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引用本文的文献

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Heliyon. 2025 Jan 9;11(2):e41725. doi: 10.1016/j.heliyon.2025.e41725. eCollection 2025 Jan 30.

本文引用的文献

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ALZHEIMER'S DISEASE--AN ELECTRON MICROSCOPICAL STUDY.阿尔茨海默病——一项电子显微镜研究。
Brain. 1964 Jun;87:307-20. doi: 10.1093/brain/87.2.307.
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Alzheimer's neurofibrillary changes. A topographic study.阿尔茨海默病神经纤维变化。一项地形学研究。
Arch Neurol. 1962 Sep;7:227-42. doi: 10.1001/archneur.1962.04210030065009.
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Reappraisal of the fine structure of Alzheimer's neurofibrillary tangles.阿尔茨海默病神经原纤维缠结精细结构的重新评估
Acta Neuropathol. 1981;54(3):239-46. doi: 10.1007/BF00687747.
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Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain.阿尔茨海默病和老年痴呆症：基底前脑神经元的丧失。
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Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.阿尔茨海默病：细胞特异性病理学揭示海马结构病变
Science. 1984 Sep 14;225(4667):1168-70. doi: 10.1126/science.6474172.
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Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein.阿尔茨海默病：一种新型脑血管淀粉样蛋白的纯化与特性的初步报告
Biochem Biophys Res Commun. 1984 May 16;120(3):885-90. doi: 10.1016/s0006-291x(84)80190-4.
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Neuritic plaques in senile dementia of Alzheimer type: a Golgi analysis in the hippocampal region.阿尔茨海默型老年痴呆症中的神经炎性斑块：海马区的高尔基染色分析
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Monoclonal antibodies show that neurofibrillary tangles and neurofilaments share antigenic determinants.单克隆抗体表明神经原纤维缠结和神经丝具有共同的抗原决定簇。
Nature. 1982 Jul 1;298(5869):84-6. doi: 10.1038/298084a0.
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Congophilic angiopathy in the pathogenesis of Alzheimer's degeneration.嗜刚果红血管病在阿尔茨海默病变性发病机制中的作用
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Changes in the monoamine containing neurones of the human CNS in senile dementia.
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