Hyman B T, Van Hoesen G W, Damasio A R, Barnes C L
Science. 1984 Sep 14;225(4667):1168-70. doi: 10.1126/science.6474172.
Examination of temporal lobe structures from Alzheimer patients reveals a specific cellular pattern of pathology of the subiculum of the hippocampal formation and layers II and IV of the entorhinal cortex. The affected cells are precisely those that interconnect the hippocampal formation with the association cortices, basal forebrain, thalamus, and hypothalamus, structures crucial to memory. This focal pattern of pathology isolates the hippocampal formation from much of its input and output and probably contributes to the memory disorder in Alzheimer patients.
对阿尔茨海默病患者颞叶结构的检查发现，海马结构的下托以及内嗅皮质的第二层和第四层存在特定的细胞病理学模式。受影响的细胞正是那些将海马结构与联合皮质、基底前脑、丘脑和下丘脑相互连接的细胞，而这些结构对记忆至关重要。这种局部病理学模式使海马结构与其大部分输入和输出隔离开来，可能是导致阿尔茨海默病患者记忆障碍的原因。
