Paovic Jelena, Paovic Predrag, Sredovic Vojislav
Department of Ophthalmology, University Clinical Center, Pasterova 2, 11000 Belgrade, Serbia.
Autoimmune Dis. 2013;2013:842673. doi: 10.1155/2013/842673. Epub 2013 Aug 29.
The aim of this study was to analyze ocular manifestations, their complications, and treatment in a sample of 40 patients with confirmed Behcet's disease. Results. Serofibrinous iridocyclitis was the most common form of uveitis (60%). Retinal periphlebitis manifested in 92.5% of cases, and periphlebitis in conjunction with periarteritis was diagnosed in 72.5% of cases. Macular edema was the most frequent complication on the posterior segment (60%) and it correlated with periphlebitis (P = 0.45) and periphlebitis associated with periarteritis (P = 0.51). Cyclosporine A and corticosteroids were used in the majority of cases (67%). Following six months of therapy, a significant improvement of visual acuity occurred in patients with initial visual acuity >0.5 on both eyes. Level of visual acuity before and after treatment had a strong significant correlation coefficient with various ocular complications. Previously proven significant increase of visual acuity in patients with macular edema depicts effectiveness of treatment in these types of ocular manifestations of Behcet's disease. Conclusions. Significant improvement of visual acuity occurred in patients with initial visual acuity >0.5 on both eyes. The highest increase in visual acuity was achieved by laser photocoagulation in combination with triamcinolone acetonide P = 0.038 < 0.050.
本研究旨在分析40例确诊为白塞病患者的眼部表现、并发症及治疗情况。结果。浆液纤维蛋白性虹膜睫状体炎是葡萄膜炎最常见的形式（60%）。视网膜静脉周围炎在92.5%的病例中出现，72.5%的病例诊断为静脉周围炎合并动脉周围炎。黄斑水肿是后段最常见的并发症（60%），且与静脉周围炎（P = 0.45）及静脉周围炎合并动脉周围炎（P = 0.51）相关。大多数病例（67%）使用了环孢素A和皮质类固醇。治疗六个月后，初始双眼视力>0.5的患者视力有显著改善。治疗前后的视力水平与各种眼部并发症有很强的显著相关系数。先前已证实黄斑水肿患者视力显著提高，表明在白塞病的这些眼部表现类型中治疗有效。结论。初始双眼视力>0.5的患者视力有显著改善。激光光凝联合曲安奈德使视力提高最为显著（P = 0.038 < 0.050）。
