Uemura Marc, Huynh Richard, Kuo Allen, Antelo Fernando, Deiss Robert, Yeh James
Department of Internal Medicine, Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Case Rep Hematol. 2013;2013:687260. doi: 10.1155/2013/687260. Epub 2013 Aug 31.
Hemophagocytic lymphohistiocytosis (HLH), while uncommon, may be a devastating complication of lymphoma and/or human immunodeficiency virus (HIV) infection. While several of the diagnostic criteria for HLH are relatively nonspecific, particularly in the setting of a systemic inflammatory response, more diagnostic specificity may be achieved with marked elevations in serum ferritin (e.g., >100,000 ng/mL). Increased suspicion of HLH, particularly in the setting of persistent, unexplained fevers, pancytopenia, and transaminitis, should prompt consideration of HLH. Earlier diagnosis and initiation of therapy have the potential to alter the natural history and poor prognosis of this disorder. We present a patient with HIV infection who developed relapsed T-cell lymphoma complicated by hemophagocytic lymphohistiocytosis.
噬血细胞性淋巴组织细胞增生症（HLH）虽不常见，但可能是淋巴瘤和/或人类免疫缺陷病毒（HIV）感染的一种严重并发症。HLH的一些诊断标准相对缺乏特异性，尤其是在全身性炎症反应的情况下，而血清铁蛋白显著升高（如>100,000 ng/mL）时可能会有更高的诊断特异性。对HLH的怀疑增加，尤其是在持续不明原因发热、全血细胞减少和转氨酶升高的情况下，应促使考虑HLH。早期诊断和开始治疗有可能改变这种疾病的自然病程和不良预后。我们报告一名患有HIV感染的患者，其复发的T细胞淋巴瘤并发噬血细胞性淋巴组织细胞增生症。
