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神经母细胞瘤相关炎症：小剂量阿司匹林是否适用于小癌症患者？

Neuroblastoma-related inflammation: May small doses of aspirin be suitable for small cancer patients?

作者信息

Carlson Lena-Maria, Kogner Per

机构信息

Childhood Cancer Research Unit; Department of Women's and Children's Health; Karolinska Institutet; Stockholm, Sweden.

出版信息

Oncoimmunology. 2013 Jul 1;2(7):e24658. doi: 10.4161/onci.24658. Epub 2013 Apr 30.

DOI:10.4161/onci.24658
PMID:24073359
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3782012/
Abstract

The daily intake of low-dose aspirin lowers the risk of several cancers among the adults. The continuous administration of low-dose aspirin to TH- mice (a model of pediatric neuroblastoma) delays tumor outgrowth and decreases tumor-promoting inflammation by inhibiting regulatory cells of the innate immune system as well as immunosuppressive mediators such as transforming growth factor β (TGFβ) and thromboxane A. These findings pave novel avenues for the clinical management of neuroblastoma.

摘要

成人每日摄入低剂量阿司匹林可降低多种癌症的风险。对TH小鼠（一种小儿神经母细胞瘤模型）持续给予低剂量阿司匹林可延缓肿瘤生长，并通过抑制先天免疫系统的调节细胞以及免疫抑制介质（如转化生长因子β（TGFβ）和血栓素A）来减轻肿瘤促进炎症。这些发现为神经母细胞瘤的临床治疗开辟了新途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c23/3782012/f06d5083870c/onci-2-e24658-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c23/3782012/f06d5083870c/onci-2-e24658-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c23/3782012/f06d5083870c/onci-2-e24658-g1.jpg

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