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肿瘤微环境中的B7x与髓源性抑制细胞：双城故事

B7x and myeloid-derived suppressor cells in the tumor microenvironment: A tale of two cities.

作者信息

Jeon Hyungjun, Ohaegbulam Kim C, Abadi Yael M, Zang Xingxing

机构信息

Department of Microbiology and Immunology; Albert Einstein College of Medicine; Bronx, NY USA.

出版信息

Oncoimmunology. 2013 Jul 1;2(7):e24744. doi: 10.4161/onci.24744. Epub 2013 Apr 30.

DOI:10.4161/onci.24744
PMID:24073367
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3782163/
Abstract

A new study demonstrates the tumorigenic functions of B7x and reveals a link between B7x and myeloid-derived suppressor cells (MDSCs) within the tumor microenvironment. We propose that the binding of B7x to a hitherto unidentified receptor on MDSCs may stimulate their proliferation and/or immunosuppressive functions, hence promoting tumor growth.

摘要

一项新研究证明了B7x的致瘤功能，并揭示了肿瘤微环境中B7x与髓源性抑制细胞（MDSC）之间的联系。我们提出，B7x与MDSC上一种迄今未明确的受体结合，可能会刺激其增殖和/或免疫抑制功能，从而促进肿瘤生长。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9144/3782163/7ae94a52973e/onci-2-e24744-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9144/3782163/7ae94a52973e/onci-2-e24744-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9144/3782163/7ae94a52973e/onci-2-e24744-g1.jpg

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B7x in the periphery abrogates pancreas-specific damage mediated by self-reactive CD8 T cells.B7x 在边缘消除了自身反应性 CD8 T 细胞介导的胰腺特异性损伤。
J Immunol. 2012 Oct 15;189(8):4165-74. doi: 10.4049/jimmunol.1201241. Epub 2012 Sep 12.
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Tissue-expressed B7x affects the immune response to and outcome of lethal pulmonary infection.组织表达的 B7x 影响致死性肺部感染的免疫应答和结果。
B7/CD28与表皮生长因子受体（EGFR）信号通路间的相互作用：作用机制与治疗机遇
Genes Dis. 2021 Sep 20;9(5):1181-1193. doi: 10.1016/j.gendis.2021.08.009. eCollection 2022 Sep.
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Soluble B7-CD28 Family Inhibitory Immune Checkpoint Proteins and Anti-Cancer Immunotherapy.可溶性 B7-CD28 家族抑制性免疫检查点蛋白与癌症免疫治疗
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