新兴的肝毒性生物标志物及其改善药物性肝损伤认识和管理的潜力。
Emerging hepatotoxicity biomarkers and their potential to improve understanding and management of drug-induced liver injury.
机构信息
Drug Safety R&D, Pfizer Inc., Eastern Point Rd, Groton, CT, USA.
Toxadvisor Toxicology Consulting, Hadlyme, CT, USA.
出版信息
Genome Med. 2013 Sep 27;5(9):85. doi: 10.1186/gm489. eCollection 2013.
Abstract
Biomarkers of drug-induced liver injury (DILI) are essential for the diagnosis of severe cases of DILI in clinical trials and clinical practice, but the currently used biomarker paradigm detects damage after it has occurred and has limited prognostic value. The development of new biomarker strategies that improve the diagnosis of DILI by providing increased specificity and/or by identifying individual patients who are at risk for DILI is therefore crucial. See related Research, http://genomemedicine.com/content/5/9/86.
摘要
药物性肝损伤（DILI）的生物标志物对于临床试验和临床实践中严重 DILI 的诊断至关重要，但目前使用的生物标志物方法仅在损伤发生后进行检测，其预后价值有限。因此，开发新的生物标志物策略对于提高 DILI 的诊断具有重要意义，这些策略可通过提高特异性和/或识别出有 DILI 风险的个体患者来实现。详见相关研究，http://genomemedicine.com/content/5/9/86。
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