Department of Ophthalmology .
Curr Eye Res. 2014 Feb;39(2):188-93. doi: 10.3109/02713683.2013.834940. Epub 2013 Sep 27.
To evaluate renal function in patients with pseudoexfoliation syndrome.
This prospective, cross-sectional, case-control study involved 49 patients with pseudoexfoliation syndrome (PEX) and 42 control subjects. Renal function was examined by biochemical parameters and Doppler ultrasonography. Serum creatinine, blood urea nitrogen, urea levels, urine microalbumin level and creatinine clearance were measured. Renal volume, resistive index and pulsatility index were calculated using Doppler ultrasonography.
The mean laboratory values for both groups were as follows: Creatinine, PEX: 0.81 ± 0.28 mg/dL - Control: 0.79 ± 0.22 mg/dL; urea, PEX: 31.6 ± 9.7 mg/dL - Control: 32.2 ± 8.4 mg/dL; blood urea nitrogen, PEX: 14.8 ± 4.6 mg/dL - Control: 15.1 ± 4.0 mg/dL; creatinine clearance, PEX: 89.1 ± 35.6 mL/min - Control: 99.0 ± 47.2 mL/min; microalbumin, PEX: 5.8 ± 22.7 mg/dL - Control: 2.7 ± 6.0 mg/dL. The differences between groups were not significant (p > 0.300). Renal volume, resistive index and pulsatility index values were similar in both groups (p > 0.200).
This study showed that pseudoexfoliation syndrome does not affect biochemical and ultrasonographic parameters associated with renal function.
评估假性剥脱综合征患者的肾功能。
这是一项前瞻性、横断面、病例对照研究，共纳入 49 例假性剥脱综合征（PEX）患者和 42 例对照者。通过生化参数和多普勒超声评估肾功能。检测血清肌酐、血尿素氮、尿素水平、尿微量白蛋白水平和肌酐清除率。使用多普勒超声计算肾体积、阻力指数和搏动指数。
两组的平均实验室值如下：肌酐，PEX：0.81±0.28mg/dL-对照：0.79±0.22mg/dL；尿素，PEX：31.6±9.7mg/dL-对照：32.2±8.4mg/dL；血尿素氮，PEX：14.8±4.6mg/dL-对照：15.1±4.0mg/dL；肌酐清除率，PEX：89.1±35.6mL/min-对照：99.0±47.2mL/min；微量白蛋白，PEX：5.8±22.7mg/dL-对照：2.7±6.0mg/dL。两组间差异无统计学意义（p>0.300）。两组的肾体积、阻力指数和搏动指数值相似（p>0.200）。
本研究表明假性剥脱综合征不影响与肾功能相关的生化和超声参数。
