Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Graefes Arch Clin Exp Ophthalmol. 2021 Oct;259(10):3027-3034. doi: 10.1007/s00417-021-05241-w. Epub 2021 Jun 25.
To investigate the relationship between exfoliation syndrome (XFS) and systemic diseases.
A population-based, retrospective study with control group was conducted using the electronic medical database of Maccabi Health Services, the second largest Health Maintenance Organization (HMO) in Israel. Study population included Maccabi members from January 2003 to April 2016. Cases consisted of patients diagnosed with XFS regardless of glaucoma. The control group included Maccabi members without XFS, matched on age, sex, and ancestry, that were examined by an ophthalmologist within the last year.
Associations between XFS and systemic diseases.
We identified 16,388 patients with XFS, in whom 40.3% (n = 6613) had glaucoma. The control group included 14,015 patients. Mean age was 78.3 ± 8.9 years and 76.2 ± 8.5 years for the XFS and control group, respectively. In unconditional logistic regression analyses, after adjusting for age, sex, and ancestry, XFS was significantly associated with risk of cardiovascular diseases including hypertension (OR 1.07, 95% CI 1.01-1.13, p = 0.02), myocardial infarction (OR 1.21, 95% CI 1.17-1.31, p < 0.0001), and congestive heart failure (OR 1.70, 95% CI 1.55-1.88, p < 0.0001) as well as higher risk for high creatinine (OR 1.28, 95% CI 1.2-1.37, p < 0.0001). Diabetes mellitus and body mass index were inversely associated with XFS (OR 0.70, 95% CI 0.67-0.73, p < 0.0001 and OR 0.88, 95% CI 0.84-0.93, p < 0.0001, respectively). Overall cancer diagnoses were more common in the XFS group (OR 1.05, 95% CI 1.0-1.1, p = 0.05). XFS was associated with more hospitalizations (mean 5 ± 5.3 hospitalizations in the XFS group and 3.3 ± 4.0 in the controls, p < 0.0001).
XFS is significantly associated with cardiovascular systemic diseases (in a population living in Israel and predominantly born in Russia).
研究剥脱综合征（XFS）与全身疾病之间的关系。
本研究采用了以人群为基础的、有对照组的回顾性研究方法，使用了以色列第二大健康维护组织（HMO）Maccabi 健康服务的电子医疗数据库。研究人群包括 2003 年 1 月至 2016 年 4 月期间的 Maccabi 成员。病例组包括所有确诊为 XFS 且无论是否患有青光眼的患者。对照组由在过去一年中经眼科医生检查过且没有 XFS 的 Maccabi 成员组成，与病例组在年龄、性别和祖籍方面相匹配。
XFS 与全身疾病之间的关联。
本研究共纳入 16388 例 XFS 患者，其中 6613 例（40.3%）患有青光眼。对照组包括 14015 例患者。XFS 组和对照组的平均年龄分别为 78.3±8.9 岁和 76.2±8.5 岁。在非条件逻辑回归分析中，调整年龄、性别和祖籍后，XFS 与心血管疾病风险显著相关，包括高血压（OR 1.07，95%CI 1.01-1.13，p=0.02）、心肌梗死（OR 1.21，95%CI 1.17-1.31，p<0.0001）和充血性心力衰竭（OR 1.70，95%CI 1.55-1.88，p<0.0001），同时还与较高的肌酐水平（OR 1.28，95%CI 1.2-1.37，p<0.0001）相关。糖尿病和体重指数与 XFS 呈负相关（OR 0.70，95%CI 0.67-0.73，p<0.0001 和 OR 0.88，95%CI 0.84-0.93，p<0.0001）。XFS 组的总体癌症诊断更为常见（OR 1.05，95%CI 1.0-1.1，p=0.05）。XFS 与更多的住院治疗相关（XFS 组平均 5±5.3 次住院治疗，对照组为 3.3±4.0 次住院治疗，p<0.0001）。
XFS 与心血管系统疾病显著相关（在一个居住在以色列、主要出生于俄罗斯的人群中）。
