Muratani H, Kimura Y, Matsumura K, Noda Y, Eto T, Fukiyama K
Third Department of Internal Medicine, School of Medicine, University of the Ryukyus, Okinawa, Japan.
Clin Exp Hypertens A. 1990;12(1):97-110. doi: 10.3109/10641969009074722.
Baroreflex function and plasma angiotensin II (Ang II) were examined in five elderly and five young or middle-aged essential hypertensive patients before and after enalapril treatment. Baroreflex sensitivity (BS) during blood pressure (BP) elevation by phenylephrine (PE) but not during BP reduction by sodium nitroprusside (SNP) was significantly attenuated in the elderly compared with the younger group, while plasma Ang II concentration was not different between the two groups. Enalapril treatment reduced BP without significant changes in heart rate and plasma norepinephrine in both groups, suggesting a leftward shift of barofunction curve. It also increased the BS in some cases in each group. However, plasma Ang II was not significantly reduced during enalapril treatment. The changes in BS did not correlate with changes in plasma Ang II. These results suggest that BS may be attenuated with increasing age independent of plasma Ang II and that ACE inhibitor influences the set point of the barofunction curve and BS by different mechanisms.
在五名老年原发性高血压患者和五名年轻或中年原发性高血压患者中，在依那普利治疗前后检测了压力反射功能和血浆血管紧张素II（Ang II）。与年轻组相比，老年组在去氧肾上腺素（PE）使血压（BP）升高期间的压力反射敏感性（BS）显著减弱，但在硝普钠（SNP）使血压降低期间则不然，而两组之间的血浆Ang II浓度并无差异。依那普利治疗使两组的血压降低，心率和血浆去甲肾上腺素无显著变化，提示压力功能曲线向左移位。在每组的一些病例中，它还增加了BS。然而，依那普利治疗期间血浆Ang II并未显著降低。BS的变化与血浆Ang II的变化无关。这些结果表明，BS可能随年龄增长而减弱，与血浆Ang II无关，且血管紧张素转换酶抑制剂通过不同机制影响压力功能曲线的设定点和BS。
