Muratani H, Kimura Y, Matsumura K, Noda Y, Eto T, Fukiyama K
Third Department of Internal Medicine, School of Medicine, University of The Ryukyus, Okinawa, Japan.
Clin Exp Hypertens A. 1988;10 Suppl 1:391-8. doi: 10.3109/10641968809075995.
We examined baroreflex function and plasma angiotensin II (Ang II) before and after the treatment with an angiotensin converting enzyme inhibitor (ACEI) in eight inpatients with essential hypertension (EHT). Baroreflex sensitivity (BS), expressed as a slope of linear relationship between %-changes in mean blood pressure (BP) and those in plasma concentration of norepinephrine (pNE), was greater during BP reduction by sodium nitroprusside (SNP) than during BP elevation by phenylephrine (PE). Enalapril treatment for 7 days reduced BP without a significant change in heart rate and pNE. It also increased the BS in two cases during SNP infusion and in four cases during PE infusion. Ang II was not significantly reduced after enalapril, while plasma ACE activity was suppressed by about 80% and plasma renin activity (PRA) was elevated. The changes in BS did not correlate with the changes in Ang II. The shift of barofunction curve with an enhancement of BS by enalapril therapy might not be attributed solely to the interaction between circulating Ang II and central baroreflex mechanisms.
我们在8例原发性高血压（EHT）住院患者中，研究了使用血管紧张素转换酶抑制剂（ACEI）治疗前后的压力反射功能和血浆血管紧张素II（Ang II）。压力反射敏感性（BS）以平均血压（BP）变化百分比与去甲肾上腺素（pNE）血浆浓度变化百分比之间的线性关系斜率表示，在硝普钠（SNP）降低血压期间比去氧肾上腺素（PE）升高血压期间更高。依那普利治疗7天可降低血压，心率和pNE无显著变化。在SNP输注期间，有2例患者的BS增加；在PE输注期间，有4例患者的BS增加。依那普利治疗后，Ang II无显著降低，而血浆ACE活性被抑制约80%，血浆肾素活性（PRA）升高。BS的变化与Ang II的变化无关。依那普利治疗使压力功能曲线发生偏移并增强了BS，这可能不仅仅归因于循环中的Ang II与中枢压力反射机制之间的相互作用。
