锰超氧化物歧化酶（MnSOD）Val16Ala、过氧化氢酶（CAT）-262 C>T和谷胱甘肽过氧化物酶1（GPx1）Pro198Leu基因多态性变体与吸烟人群喉癌风险
Polymorphic variants of MnSOD Val16Ala, CAT-262 C < T and GPx1 Pro198Leu genotypes and the risk of laryngeal cancer in a smoking population.
作者信息
Aynali G, Doğan M, Sütcü R, Yüksel O, Yariktaş M, Unal F, Yasan H, Ceyhan B, Tüz M
机构信息
Department of Ear, Nose and Throat - Head and Neck Surgery, School of Medicine, Süleyman Demirel University, Isparta.
出版信息
J Laryngol Otol. 2013 Oct;127(10):997-1000. doi: 10.1017/S0022215113002028. Epub 2013 Sep 30.
OBJECTIVE
To investigate the relationship between development of laryngeal cancer and the presence of polymorphisms of the MnSOD Val16Ala, CAT-262 C < T and GPx1 Pro198Leu genes in a smoking population.
PATIENTS AND METHODS
Single nucleotide polymorphisms were determined in DNA from the peripheral blood erythrocytes of 48 heavy smokers (25 patients with laryngeal cancer and 23 cancer-free controls), using polymerase chain reaction.
RESULTS
There were no significant differences in age, smoking duration or smoking intensity, comparing the two groups. The homozygous AA genotype of MnSOD Val16Ala was significantly more prevalent in the cancer group than the control group (92 vs 13 per cent, respectively), while the heterozygous AV genotype of MnSOD Val16Ala was more prevalent in the control group than the cancer group (87 vs 8 per cent, respectively) (p < 0.001). There were no significant differences between the cancer and control groups regarding GPx1 Pro198Leu or CAT-262 C < T polymorphisms.
CONCLUSION
Polymorphism of the MnSOD Val16Ala gene may contribute to susceptibility to laryngeal cancer among smokers.
目的
研究吸烟人群中喉癌发生与锰超氧化物歧化酶（MnSOD）Val16Ala、过氧化氢酶（CAT）-262 C>T和谷胱甘肽过氧化物酶1（GPx1）Pro198Leu基因多态性之间的关系。
患者与方法
采用聚合酶链反应测定48名重度吸烟者（25例喉癌患者和23例无癌对照者）外周血红细胞DNA中的单核苷酸多态性。
结果
两组在年龄、吸烟持续时间或吸烟强度方面无显著差异。MnSOD Val16Ala的纯合子AA基因型在癌症组中的患病率显著高于对照组（分别为92%和13%），而MnSOD Val16Ala的杂合子AV基因型在对照组中的患病率高于癌症组（分别为87%和8%）（p<0.001）。癌症组和对照组在GPx1 Pro198Leu或CAT-262 C>T多态性方面无显著差异。
结论
MnSOD Val16Ala基因多态性可能导致吸烟者易患喉癌。
Zotero 插件