Vega-Catalan F J
Computer Science Department, University of Ibadan, Nigeria.
Comput Biomed Res. 1990 Feb;23(1):1-9. doi: 10.1016/0010-4809(90)90002-t.
A user-friendly program coded in PASCAL for the IBM PC has been developed to determine the etiology of impaired glucose tolerance using an intravenous glucose tolerance test (IVGTT). It makes use of the "minimal modeling technique," a method that has been shown to be adequate for the quantitative determination of insulin sensitivity and insulin resistance. Two models are used, the minimal model of glucose disappearance and the minimal model of insulin kinetics. The first model is described by two nonlinear ordinary differential equations (ODEs) which are solved numerically, and which yield the insulin sensitivity index SI. The second model is described by an ODE for which an explicit solution was obtained, and which yields the pancreatic responsivity parameters phi 1 and phi 2. The product SI.phi 2 can be used to segregate subjects into "good" and "low" tolerance types. The program provides best-fit plots along with numerical values of the parameters and their uncertainties, and requires little intervention from the user. The fact that it requires a noninvasive IVGTT as input and that it has been written for the ubiquitous IBM PC are added advantages.
已开发出一个用PASCAL语言为IBM个人电脑编写的用户友好程序，用于通过静脉葡萄糖耐量试验（IVGTT）确定糖耐量受损的病因。它采用了“最小模型技术”，这是一种已被证明足以定量测定胰岛素敏感性和胰岛素抵抗的方法。使用了两种模型，即葡萄糖消失的最小模型和胰岛素动力学的最小模型。第一个模型由两个非线性常微分方程（ODE）描述，通过数值求解这些方程可得出胰岛素敏感性指数SI。第二个模型由一个ODE描述，已获得其显式解，通过该解可得出胰腺反应性参数phi 1和phi 2。SI.phi 2的乘积可用于将受试者分为“良好”和“低”耐量类型。该程序提供最佳拟合图以及参数的数值及其不确定性，并且几乎不需要用户干预。它需要无创IVGTT作为输入且是为普遍使用的IBM个人电脑编写的，这些都是额外的优点。
