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本文引用的文献

1
Characteristics and outcomes of culture-negative versus culture-positive severe sepsis.血培养阴性与血培养阳性严重脓毒症的特征及预后
Crit Care. 2013 Sep 12;17(5):R202. doi: 10.1186/cc12896.
2
Multiplex PCR system for rapid detection of pathogens in patients with presumed sepsis - a systemic review and meta-analysis.用于快速检测疑似败血症患者病原体的多重 PCR 系统：系统评价和荟萃分析。
PLoS One. 2013 May 29;8(5):e62323. doi: 10.1371/journal.pone.0062323. Print 2013.
3
Sepsis definitions: time for change.脓毒症的定义：是时候改变了。
Lancet. 2013 Mar 2;381(9868):774-5. doi: 10.1016/S0140-6736(12)61815-7.
4
Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012.拯救脓毒症运动：严重脓毒症和脓毒性休克管理国际指南：2012 年。
Crit Care Med. 2013 Feb;41(2):580-637. doi: 10.1097/CCM.0b013e31827e83af.
5
Evaluation of a polymerase chain reaction assay for pathogen detection in septic patients under routine condition: an observational study.在常规条件下对脓毒症患者进行病原体检测的聚合酶链反应检测评估：一项观察性研究。
PLoS One. 2012;7(9):e46003. doi: 10.1371/journal.pone.0046003. Epub 2012 Sep 27.
6
Viral infection in patients with severe pneumonia requiring intensive care unit admission.重症肺炎患者需要入住重症监护病房的病毒感染。
Am J Respir Crit Care Med. 2012 Aug 15;186(4):325-32. doi: 10.1164/rccm.201112-2240OC. Epub 2012 Jun 14.
7
Outcomes in severe sepsis and patients with septic shock: pathogen species and infection sites are not associated with mortality.严重脓毒症和感染性休克患者的结局：病原体种类和感染部位与死亡率无关。
Crit Care Med. 2011 Aug;39(8):1886-95. doi: 10.1097/CCM.0b013e31821b827c.
8
A multicenter trial to compare blood culture with polymerase chain reaction in severe human sepsis.多中心试验比较菌血症患者血液培养与聚合酶链反应。
Intensive Care Med. 2010 Feb;36(2):241-7. doi: 10.1007/s00134-009-1705-z. Epub 2009 Nov 19.
9
Predisposition, insult/infection, response, and organ dysfunction: A new model for staging severe sepsis.易感性、损伤/感染、反应及器官功能障碍：一种严重脓毒症分期的新模型
Crit Care Med. 2009 Apr;37(4):1329-35. doi: 10.1097/CCM.0b013e31819d5db1.
10
Sepsis in European intensive care units: results of the SOAP study.欧洲重症监护病房的脓毒症：SOAP研究结果
Crit Care Med. 2006 Feb;34(2):344-53. doi: 10.1097/01.ccm.0000194725.48928.3a.

血培养阴性的严重脓毒症，检查无异常发现

Unrevealing culture-negative severe sepsis.

作者信息

de Prost Nicolas, Razazi Keyvan, Brun-Buisson Christian

出版信息

Crit Care. 2013 Sep 26;17(5):1001. doi: 10.1186/cc13022.

DOI:10.1186/cc13022
PMID:24074289
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4056359/
Abstract

Sepsis involves a wide array of sources and microorganisms, only a fraction of which are microbiologically documented. Culture-negative sepsis poses special diagnostic challenges to both clinicians and microbiologists and further questions the validity of sepsis definitions.

摘要

脓毒症涉及多种来源和微生物，其中只有一小部分有微生物学记录。血培养阴性的脓毒症给临床医生和微生物学家都带来了特殊的诊断挑战，并进一步质疑了脓毒症定义的有效性。