Laboratory of Hematology-Oncology, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy.
Breast. 2013 Aug;22 Suppl 2:S48-9. doi: 10.1016/j.breast.2013.07.009.
INTRODUCTION/AIMS: Obesity, an excess accumulation of adipose tissue occurring in mammalians when caloric intake exceeds energy expenditure, is associated with an increased incidence, morbidity and mortality from several types of neoplastic diseases including postmenopausal breast cancer.
Several investigators have recently studied the role of human white adipose tissue (WAT) progenitors in preclinical models of breast cancer. WAT progenitors were found to promote breast cancer local growth, angiogenesis, EMT, migration and metastatic spreading. Breast cancer patients with intraepithelial neoplasia who received autologous WAT cells for breast reconstruction after surgical removal of breast cancer showed an increased risk of recurrence of local events when compared to controls.
DISCUSSION/CONCLUSION: There is an urgent need for a better understanding of the role of WAT progenitors in breast cancer local and metastatic growth. A rigorous cancer screening and follow-up of patients enrolled for WAT progenitor-based therapies should be implemented.
简介/目的：肥胖是哺乳动物中由于热量摄入超过能量消耗而导致的脂肪组织过度积累，与多种类型的肿瘤性疾病（包括绝经后乳腺癌）的发病率、发病率和死亡率增加有关。
最近，一些研究人员研究了人类白色脂肪组织（WAT）祖细胞在乳腺癌临床前模型中的作用。研究发现，WAT 祖细胞促进乳腺癌的局部生长、血管生成、上皮间质转化、迁移和转移扩散。与对照组相比，接受乳腺癌手术后乳房重建时自体 WAT 细胞的上皮内瘤变乳腺癌患者局部复发的风险增加。
讨论/结论：迫切需要更好地了解 WAT 祖细胞在乳腺癌局部和转移性生长中的作用。应针对接受基于 WAT 祖细胞治疗的患者进行严格的癌症筛查和随访。
