Centre of Excellence for Research in AIDS, University of Malaya, Kuala Lumpur, Malaysia.
J Subst Abuse Treat. 2014 Feb;46(2):144-9. doi: 10.1016/j.jsat.2013.08.023. Epub 2013 Sep 24.
People who use drugs (PWUD) represent a key high risk group for tuberculosis (TB). The prevalence of both latent TB infection (LTBI) and active disease in drug treatment centers in Malaysia is unknown. A cross-sectional convenience survey was conducted to assess the prevalence and correlates of LTBI among attendees at a recently created voluntary drug treatment center using a standardized questionnaire and tuberculin skin testing (TST). Participants (N=196) were mostly men (95%), under 40 (median age=36 years) and reported heroin use immediately before treatment entry (75%). Positive TST prevalence was 86.7%. Nine (4.6%) participants were HIV-infected. Previous arrest/incarcerations (AOR=1.1 for every entry, p<0.05) and not being HIV-infected (AOR=6.04, p=0.03) were significantly associated with TST positivity. There is an urgent need to establish TB screening and treatment programs in substance abuse treatment centers and to tailor service delivery to the complex treatment needs of patients with multiple medical and psychiatric co-morbidities.
吸毒者（PWUD）是结核病（TB）的一个主要高危群体。马来西亚毒品治疗中心潜伏性结核感染（LTBI）和活动性疾病的患病率尚不清楚。本横断面便利调查旨在使用标准化问卷和结核菌素皮肤试验（TST）评估新成立的自愿戒毒治疗中心参与者中 LTBI 的患病率及其相关因素。参与者（N=196）主要为男性（95%），年龄在 40 岁以下（中位数年龄=36 岁），并报告在治疗开始前使用海洛因（75%）。TST 阳性率为 86.7%。9 名（4.6%）参与者感染了 HIV。既往被捕/监禁（每增加一次 AOR=1.1，p<0.05）和未感染 HIV（AOR=6.04，p=0.03）与 TST 阳性显著相关。迫切需要在药物滥用治疗中心建立结核病筛查和治疗计划，并根据患有多种医学和精神共病患者的复杂治疗需求调整服务提供。
