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Vasorelaxant and antihypertensive effects of methanolic fraction of the essential oil of Alpinia zerumbet.山柰酚的精油的甲醇部分的血管舒张和降压作用。
Vascul Pharmacol. 2013 May-Jun;58(5-6):337-45. doi: 10.1016/j.vph.2013.04.001. Epub 2013 Apr 18.
2
Catharanthine dilates small mesenteric arteries and decreases heart rate and cardiac contractility by inhibition of voltage-operated calcium channels on vascular smooth muscle cells and cardiomyocytes.卡特兰定通过抑制血管平滑肌细胞和心肌细胞上的电压门控钙通道来扩张小肠系膜动脉，并降低心率和心肌收缩力。
J Pharmacol Exp Ther. 2013 Jun;345(3):383-92. doi: 10.1124/jpet.112.199661. Epub 2013 Mar 26.
3
Ex vivo study of the vasorelaxant activity induced by phenanthrene derivatives isolated from Maxillaria densa.从密花石豆兰中分离得到的菲衍生物的血管舒张活性的离体研究。
J Nat Prod. 2012 Dec 28;75(12):2241-5. doi: 10.1021/np300508v. Epub 2012 Dec 12.
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Vasorelaxant effect of flavonoids through calmodulin inhibition: Ex vivo, in vitro, and in silico approaches.通过钙调蛋白抑制发挥类黄酮的血管舒张作用：离体、在体和计算方法。
Bioorg Med Chem. 2011 Jan 1;19(1):542-6. doi: 10.1016/j.bmc.2010.10.063. Epub 2010 Nov 4.
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Phenolic composition and antioxidant activities of 11 celery cultivars.11 种芹菜品种的酚类成分和抗氧化活性。
J Food Sci. 2010 Jan-Feb;75(1):C9-13. doi: 10.1111/j.1750-3841.2009.01392.x.
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Vasorelaxant and antihypertensive effects of methanolic extract from roots of Laelia anceps are mediated by calcium-channel antagonism.Laelia anceps 根甲醇提取物的血管舒张和降压作用是通过钙通道拮抗介导的。
Fitoterapia. 2010 Jul;81(5):350-7. doi: 10.1016/j.fitote.2009.10.009. Epub 2009 Oct 30.
7
Triterpenoids and flavonoids from celery (Apium graveolens).芹菜（旱芹）中的三萜类化合物和黄酮类化合物。
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8
Antihypertensive and vasorelaxant effects of tilianin isolated from Agastache mexicana are mediated by NO/cGMP pathway and potassium channel opening.从墨西哥藿香中分离出的田蓟苷的降压和血管舒张作用是通过NO/cGMP途径和钾通道开放介导的。
Biochem Pharmacol. 2009 Jul 1;78(1):54-61. doi: 10.1016/j.bcp.2009.03.016. Epub 2009 Mar 27.
9
Endothelium-dependent and -independent relaxation induced by pinocembrin in rat aortic rings.白杨素对大鼠主动脉环的内皮依赖性和非内皮依赖性舒张作用
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芹菜提取物的血管舒张活性：分离具有潜在降压作用的血管舒张分子的可能来源。

Vasorelaxant activity of extracts obtained from Apium graveolens: possible source for vasorelaxant molecules isolation with potential antihypertensive effect.

作者信息

Jorge Vergara-Galicia, Ángel Jimenez-Ramirez Luis, Adrián Tun-Suarez, Francisco Aguirre-Crespo, Anuar Salazar-Gómez, Samuel Estrada-Soto, Ángel Sierra-Ovando, Emmanuel Hernandez-Nuñez

机构信息

Division of Health Sciences, University of Quintana roo, Chetumal, Quintana Roo, Mexico.

出版信息

Asian Pac J Trop Biomed. 2013 Oct;3(10):776-9. doi: 10.1016/S2221-1691(13)60154-9. Epub 2013 Sep 4.

DOI:10.1016/S2221-1691(13)60154-9
PMID:24075341
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3761135/
Abstract

OBJECTIVE

To investigate vasorelaxant effect of organic extracts from Apium graveolens (A. graveolens) which is a part of a group of plants subjected to pharmacological and phytochemical study with the purpose of offering it as an ideal source for obtaining lead compounds for designing new therapeutic agents with potential vasorelaxant and antihypertensive effects.

METHODS

An ex vivo method was employed to assess the vasorelaxant activity. This consisted of using rat aortic rings with and without endothelium precontracted with norepinephrine.

RESULTS

All extracts caused concentration-dependent relaxation in precontracted aortic rings with and without endothelium; the most active extracts were Dichloromethane and Ethyl Acetate extracts from A. graveolens. These results suggested that secondary metabolites responsible for the vasorelaxant activity belong to a group of compounds of medium polarity. Also, our evidence showed that effect induced by dichloromethane and ethyl acetate extracts from A. graveolens is mediated probably by calcium antagonism.

CONCLUSIONS

A. graveolens represents an ideal source for obtaining lead compounds for designing new therapeutic agents with potential vasorelaxant and antihypertensive effects.

摘要

目的

芹菜是一组接受药理和植物化学研究的植物的一部分，本研究旨在探讨芹菜有机提取物的血管舒张作用，以便将其作为获取先导化合物的理想来源，用于设计具有潜在血管舒张和降压作用的新型治疗药物。

方法

采用离体方法评估血管舒张活性。该方法包括使用去甲肾上腺素预收缩的有内皮和无内皮大鼠主动脉环。

结果

所有提取物均使预收缩的有内皮和无内皮主动脉环产生浓度依赖性舒张；最具活性的提取物是芹菜的二氯甲烷提取物和乙酸乙酯提取物。这些结果表明，负责血管舒张活性的次生代谢产物属于一组中等极性的化合物。此外，我们的证据表明，芹菜二氯甲烷提取物和乙酸乙酯提取物诱导的效应可能是由钙拮抗作用介导的。

结论

芹菜是获取先导化合物的理想来源，可用于设计具有潜在血管舒张和降压作用的新型治疗药物。