芹菜提取物的血管舒张活性：分离具有潜在降压作用的血管舒张分子的可能来源。
Vasorelaxant activity of extracts obtained from Apium graveolens: possible source for vasorelaxant molecules isolation with potential antihypertensive effect.
作者信息
Jorge Vergara-Galicia, Ángel Jimenez-Ramirez Luis, Adrián Tun-Suarez, Francisco Aguirre-Crespo, Anuar Salazar-Gómez, Samuel Estrada-Soto, Ángel Sierra-Ovando, Emmanuel Hernandez-Nuñez
机构信息
Division of Health Sciences, University of Quintana roo, Chetumal, Quintana Roo, Mexico.
出版信息
Asian Pac J Trop Biomed. 2013 Oct;3(10):776-9. doi: 10.1016/S2221-1691(13)60154-9. Epub 2013 Sep 4.
OBJECTIVE
To investigate vasorelaxant effect of organic extracts from Apium graveolens (A. graveolens) which is a part of a group of plants subjected to pharmacological and phytochemical study with the purpose of offering it as an ideal source for obtaining lead compounds for designing new therapeutic agents with potential vasorelaxant and antihypertensive effects.
METHODS
An ex vivo method was employed to assess the vasorelaxant activity. This consisted of using rat aortic rings with and without endothelium precontracted with norepinephrine.
RESULTS
All extracts caused concentration-dependent relaxation in precontracted aortic rings with and without endothelium; the most active extracts were Dichloromethane and Ethyl Acetate extracts from A. graveolens. These results suggested that secondary metabolites responsible for the vasorelaxant activity belong to a group of compounds of medium polarity. Also, our evidence showed that effect induced by dichloromethane and ethyl acetate extracts from A. graveolens is mediated probably by calcium antagonism.
CONCLUSIONS
A. graveolens represents an ideal source for obtaining lead compounds for designing new therapeutic agents with potential vasorelaxant and antihypertensive effects.
目的
芹菜是一组接受药理和植物化学研究的植物的一部分，本研究旨在探讨芹菜有机提取物的血管舒张作用，以便将其作为获取先导化合物的理想来源，用于设计具有潜在血管舒张和降压作用的新型治疗药物。
方法
采用离体方法评估血管舒张活性。该方法包括使用去甲肾上腺素预收缩的有内皮和无内皮大鼠主动脉环。
结果
所有提取物均使预收缩的有内皮和无内皮主动脉环产生浓度依赖性舒张；最具活性的提取物是芹菜的二氯甲烷提取物和乙酸乙酯提取物。这些结果表明，负责血管舒张活性的次生代谢产物属于一组中等极性的化合物。此外，我们的证据表明，芹菜二氯甲烷提取物和乙酸乙酯提取物诱导的效应可能是由钙拮抗作用介导的。
结论
芹菜是获取先导化合物的理想来源，可用于设计具有潜在血管舒张和降压作用的新型治疗药物。
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