芹菜（旱芹）中的三萜类化合物和黄酮类化合物。

Triterpenoids and flavonoids from celery (Apium graveolens).

作者信息

Zhou Kailan, Zhao Feng, Liu Zhihui, Zhuang Yulei, Chen Lixia, Qiu Feng

机构信息

Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.

出版信息

J Nat Prod. 2009 Sep;72(9):1563-7. doi: 10.1021/np900117v.

DOI:10.1021/np900117v

PMID:19778086

Abstract

Three new triterpenoids, 11,21-dioxo-2beta,3beta,15alpha-trihydroxyurs-12-ene-2-O-beta-D-glucopyranoside (1), 11,21-dioxo-3beta,15alpha,24-trihydroxyurs-12-ene-24-O-beta-D-glucopyranoside (2), and 11,21-dioxo-3beta,15alpha,24-trihydroxyolean-12-ene-24-O-beta-D-glucopyranoside (3), and two new flavonoids, apigenin-7-O-[2''-O-(5'''-O-feruloyl)-beta-D-apiofuranosyl]-beta-D-glucopyranoside (4) and chrysoeriol-7-O-[2''-O-(5'''-O-feruloyl)-beta-D-apiofuranosyl]-beta-d-glucopyranoside (5), were isolated from the whole plant of fresh celery (Apium graveolens), together with 10 known flavonoids. The structures of the new compounds were elucidated by analysis of spectroscopic data. The inhibitory effects of the compounds isolated on nitric oxide production in lipopolysaccaride-activated macrophages were evaluated.

摘要

从新鲜芹菜（Apium graveolens）全株中分离出3个新的三萜类化合物，即11,21-二氧代-2β,3β,15α-三羟基乌苏-12-烯-2-O-β-D-吡喃葡萄糖苷（1）、11,21-二氧代-3β,15α,24-三羟基乌苏-12-烯-24-O-β-D-吡喃葡萄糖苷（2）和11,21-二氧代-3β,15α,24-三羟基齐墩果-12-烯-24-O-β-D-吡喃葡萄糖苷（3），以及2个新的黄酮类化合物，芹菜素-7-O-[2''-O-(5'''-O-阿魏酰基)-β-D-芹菜呋喃糖基]-β-D-吡喃葡萄糖苷（4）和白杨素-7-O-[2''-O-(5'''-O-阿魏酰基)-β-D-芹菜呋喃糖基]-β-D-吡喃葡萄糖苷（5），同时还分离出10个已知的黄酮类化合物。通过光谱数据分析阐明了新化合物的结构。评估了所分离化合物对脂多糖激活的巨噬细胞中一氧化氮产生的抑制作用。