Department of Diabetes, Endocrinology and Nutrition, Institut d'Investigació Biomèdica de Girona (IdIBGi), CIBEROBN (CB06/03/010) and Instituto de Salud Carlos III (ISCIII), Girona, Spain.
Atherosclerosis. 2013 Oct;230(2):223-7. doi: 10.1016/j.atherosclerosis.2013.07.004. Epub 2013 Jul 18.
Recently, serum lipopolysaccharide-binding protein (LBP) has been closely associated with coronary artery disease. Here, we aimed to investigate the possible relationship between serum LBP and markers of atherosclerosis.
Serum LBP and carotid intima media thickness (C-IMT) were measured in 332 subjects (101 men and 231 women) who were recruited from an ongoing multicenter project.
Serum LBP was significantly associated with obesity [BMI, fat mass and waist circumference (r > 0.38, p < 0.0001)], HOMA (r = 0.36, p < 0.0001) and high sensitivity CRP (hsCRP) (r = 0.50, p < 0.0001). Circulating LBP was also positively associated with C-IMT (r = 0.27, p < 0.0001). Circulating LBP (β = 0.16; p = 0.001) contributed independently to C-IMT variance, after controlling for the effects of age, gender, BMI and hsCRP. Of note, circulating LBP was found to be increased in the population with carotid plaque (n = 50; 32.7 ± 12.5 vs 28.7 ± 10.7; p = 0.021).
The consistent association between serum LBP and the carotid intima media thickness, a widely used atherosclerosis marker, reveals serum LBP as a putative factor related to atherosclerosis.
最近，血清脂多糖结合蛋白（LBP）与冠状动脉疾病密切相关。在此，我们旨在研究血清 LBP 与动脉粥样硬化标志物之间的可能关系。
在一项正在进行的多中心项目中，招募了 332 名受试者（101 名男性和 231 名女性），测量了他们的血清 LBP 和颈动脉内膜中层厚度（C-IMT）。
血清 LBP 与肥胖[BMI、脂肪量和腰围（r>0.38，p<0.0001）]、HOMA（r=0.36，p<0.0001）和高敏 C 反应蛋白（hsCRP）（r=0.50，p<0.0001）显著相关。循环 LBP 也与 C-IMT 呈正相关（r=0.27，p<0.0001）。在校正年龄、性别、BMI 和 hsCRP 的影响后，循环 LBP（β=0.16；p=0.001）对 C-IMT 变异有独立贡献。值得注意的是，在颈动脉斑块患者中（n=50；32.7±12.5 比 28.7±10.7；p=0.021）发现循环 LBP 增加。
血清 LBP 与颈动脉内膜中层厚度（一种广泛使用的动脉粥样硬化标志物）之间的一致性关联表明，血清 LBP 是与动脉粥样硬化相关的一个潜在因素。
