Geneva, Switzerland; Rockville, Md.; Fairfax, Va.; and Cary and Chapel Hill, N.C. From private practice; Laboratoire Viollier Weintraub; MedImage, Radiology Center; Cary Skin Center; and the Department of Dermatology, University of North Carolina at Chapel Hill.
Plast Reconstr Surg. 2013 Oct;132(4 Suppl 2):59S-68S. doi: 10.1097/PRS.0b013e31829a02fb.
With the proliferation of dermal fillers in the aesthetic workplace have come instructions from various manufacturers regarding dermal placement. Determination of injection needle location in the dermis has in large part been based on physician expertise, product and needle familiarity, and patient-specific skin characteristics. An understanding of the precise depth of dermal structures may help practitioners improve injection specificity. Unlike other dermal fillers that suggest intradermal and deep dermal injection planes, a new hyaluronic acid with a cohesive polydensified matrix may be more appropriate for the superficial dermis because of its structure and its high degree of integration into the dermis. To that end, the authors designed a small study to quantify the depth of the superficial dermis by means of ultrasound and histology. Using ultrasound resources, the authors determined the depths of the epidermis, the dermis, and the reticular dermis in the buttocks of six patients; the authors then extrapolated the depth of the superficial reticular dermis. Histologic studies of two of the patients showed full integration of the product in the reticular dermis. Following determination of injection depths and filler integration, the authors describe a technique ("blanching") for injection of the cohesive polydensified matrix hyaluronic acid into the superficial dermis. At this time, blanching is appropriate only for injection of the cohesive polydensified matrix hyaluronic acid known as Belotero Balance in the United States, although it may have applications for other hyaluronic acid products outside of the United States.
随着美容领域中小分子玻尿酸填充剂的广泛应用,不同制造商对真皮内注射位置的指示也层出不穷。真皮内注射部位的确定在很大程度上依赖于医生的专业知识、产品和注射针熟悉程度以及患者的皮肤特点。了解真皮结构的精确深度可能有助于提高注射的特异性。与其他建议真皮内和深层真皮注射平面的真皮填充剂不同,由于其结构和与真皮高度融合,一种新型的具有粘性聚合基质的透明质酸可能更适合浅层真皮。为此,作者设计了一项小型研究,通过超声和组织学来量化浅层真皮的深度。作者使用超声资源确定了 6 名患者臀部的表皮、真皮和网状真皮的深度;然后推断出浅层网状真皮的深度。对其中 2 名患者的组织学研究显示,该产品完全整合到了网状真皮中。在确定注射深度和填充物整合后,作者描述了一种将粘性聚合基质透明质酸注射到浅层真皮的技术(“发白”)。目前,发白技术仅适用于注射在美国被称为 Belotero Balance 的粘性聚合基质透明质酸,尽管它可能适用于美国以外的其他透明质酸产品。