新型酰基硫脲与海因的合成与活性。

Synthesis and activity of novel acylthiourea with hydantoin.

机构信息

Department of Applied Chemistry, China Agricultural University, Beijing 100193, China.

出版信息

Int J Mol Sci. 2013 Sep 26;14(10):19526-39. doi: 10.3390/ijms141019526.

DOI:10.3390/ijms141019526

PMID:24077124

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3821571/

Abstract

The 41 novel acylthiourea derivatives with hydantoin were synthesized in moderate to excellent yields by using 5-(4-aminophenyl)- and 5-(4-aminobenzyl)-hydantoin or 5-(4-aminobenzyl)-thiohydantoin as raw materials and characterized by IR, 1H NMR spectra and elementary analysis. The preliminary bioassay showed that these compounds exhibit certain selectively herbicidal activities with the 91%, 94% and 87% inhibition rates of 7l, 8o and 8p against B. campestris, 100%, 100% and 95% efficacy against B. campestris in a greenhouse test, respectively. 7a, 7b, 7c and 7d exhibited 74%, 79%, 79% and 71% inhibition rates against F. oxysporum, respectively.

摘要

以 5-(4-氨基苯基)-和 5-(4-氨基苄基)-海因或 5-(4-氨基苄基)-硫代海因为原料，合成了 41 种新型酰基硫脲衍生物，产率中等至优秀。通过红外光谱、1H NMR 谱和元素分析对其进行了表征。初步生物测定表明，这些化合物具有一定的选择性除草活性，在温室试验中对油菜的抑制率分别为 7l、8o 和 8p 的 91%、94%和 87%，对油菜的抑制率为 100%、100%和 95%。7a、7b、7c 和 7d 对 F. oxysporum 的抑制率分别为 74%、79%、79%和 71%。