5-(4-羟苄基)-2-硫代亚氨代二氢-4(3H)-酮酯的合成与除草活性。
Synthesis and herbicidal activity of 5-(4-hydroxybenzyl)-2-thioxoimidazolidin-4-one esters.
机构信息
Department of Applied Chemistry, China Agricultural University, Beijing 100193, China.
出版信息
Molecules. 2011 Mar 30;16(4):2833-45. doi: 10.3390/molecules16042833.
A series of novel 5-(4-hydroxybenzyl)-2-thioxoimidazolidin-4-one esters were synthesized under mild conditions by the reaction of 5-(4-hydroxybenzyl)-2-thioxoimidazolidin-4-one and carboxylic acids with DCC and DMAP as the promoters. Their structures were confirmed by ¹H-NMR, IR, ESI-MS and elemental analysis. The preliminary bioassy results indicated that some of compounds exhibit good herbicidal activity against Zea mays, Triticum aestivum and Arabidopsis thaliana. The further greenhouse test showed that compounds 6-16 and 6-28 have 60%, 50% and 50% efficacy against Stellaria media, Echinochloa crus-galli and Setaria viridis at 1,000 g/ha, respectively.
一系列新型 5-(4-羟苄基)-2-硫代-咪唑烷-4-酮酯在温和条件下通过 5-(4-羟苄基)-2-硫代-咪唑烷-4-酮和羧酸与 DCC 和 DMAP 作为促进剂的反应合成。它们的结构通过 1H-NMR、IR、ESI-MS 和元素分析得到确认。初步的生物测定结果表明，一些化合物对玉米、小麦和拟南芥具有良好的除草活性。进一步的温室试验表明，化合物 6-16 和 6-28 在 1,000 g/ha 下对繁缕、稗草和马唐的防治效果分别为 60%、50%和 50%。
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