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乙状窦后入路切除前庭神经鞘瘤后的长期听力结果。

Long-term hearing outcome after retrosigmoid removal of vestibular schwannoma.

作者信息

Nakamizo Akira, Mori Megumu, Inoue Daisuke, Amano Toshiyuki, Mizoguchi Masahiro, Yoshimoto Koji, Sasaki Tomio

机构信息

Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University.

出版信息

Neurol Med Chir (Tokyo). 2013;53(10):688-94. doi: 10.2176/nmc.oa2012-0351. Epub 2013 Sep 27.

Abstract

Although many investigators have reported the hearing function in the immediate postoperative period in patients with vestibular schwannoma (VS), little is known about the long-term outcomes of the postoperative hearing. The aim of this study was to analyze the long-term hearing outcomes at a mean follow-up of 5 years in patients with unilateral VS treated via the retrosigmoid approach. Twenty-four patients with immediate postoperative serviceable hearing who underwent repeated audiogram or phone interview were included in this study. During the mean follow-up period (68.8 ± 30.2 months, range 14-123 months), serviceable hearing was preserved in 20 out of the 24 patients (83%). Pure tone average (PTA) was reevaluated within 6 months in seven patients. In the two patients whose PTA deteriorated ≥ 5 dB in 6 months after surgery, their PTA worsened ≥ 15 dB compared to the immediate postoperative PTA. In the remaining five patients whose PTA deteriorated < 5 dB in 6 months after surgery, PTA was maintained within a 15-dB deterioration at the final follow-up (p = 0.04, Fisher's exact test). According to Kaplan-Meier survival plots, the 5-year or 7-year preservation rate of serviceable hearing was 86.2% or 71.8%, respectively. Further study will be needed to clarify the mechanism underlying the long-term decline of serviceable hearing; however, the deterioration of PTA in the early postoperative period may help to predict the long-term outcomes of hearing.

摘要

尽管许多研究者报告了前庭神经鞘瘤(VS)患者术后即刻的听力功能,但对于术后听力的长期预后却知之甚少。本研究的目的是分析采用乙状窦后入路治疗的单侧VS患者在平均5年随访期的长期听力预后。本研究纳入了24例术后即刻听力可用且接受了多次听力图检查或电话访谈的患者。在平均随访期(68.8±30.2个月,范围14 - 123个月)内,24例患者中有20例(83%)的可用听力得以保留。7例患者在6个月内重新评估了纯音平均听阈(PTA)。在术后6个月内PTA恶化≥5 dB的2例患者中,与术后即刻的PTA相比,其PTA恶化≥15 dB。在术后6个月内PTA恶化<5 dB的其余5例患者中,最终随访时PTA维持在恶化15 dB以内(p = 0.04,Fisher精确检验)。根据Kaplan-Meier生存曲线,可用听力的5年或7年保留率分别为86.2%或71.8%。需要进一步研究以阐明可用听力长期下降的潜在机制;然而,术后早期PTA的恶化可能有助于预测听力的长期预后。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/728b/4508745/84599fa31fa2/nmc-53-688-g1.jpg

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