Nakamizo Akira, Mori Megumu, Inoue Daisuke, Amano Toshiyuki, Mizoguchi Masahiro, Yoshimoto Koji, Sasaki Tomio
Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University.
Neurol Med Chir (Tokyo). 2013;53(10):688-94. doi: 10.2176/nmc.oa2012-0351. Epub 2013 Sep 27.
Although many investigators have reported the hearing function in the immediate postoperative period in patients with vestibular schwannoma (VS), little is known about the long-term outcomes of the postoperative hearing. The aim of this study was to analyze the long-term hearing outcomes at a mean follow-up of 5 years in patients with unilateral VS treated via the retrosigmoid approach. Twenty-four patients with immediate postoperative serviceable hearing who underwent repeated audiogram or phone interview were included in this study. During the mean follow-up period (68.8 ± 30.2 months, range 14-123 months), serviceable hearing was preserved in 20 out of the 24 patients (83%). Pure tone average (PTA) was reevaluated within 6 months in seven patients. In the two patients whose PTA deteriorated ≥ 5 dB in 6 months after surgery, their PTA worsened ≥ 15 dB compared to the immediate postoperative PTA. In the remaining five patients whose PTA deteriorated < 5 dB in 6 months after surgery, PTA was maintained within a 15-dB deterioration at the final follow-up (p = 0.04, Fisher's exact test). According to Kaplan-Meier survival plots, the 5-year or 7-year preservation rate of serviceable hearing was 86.2% or 71.8%, respectively. Further study will be needed to clarify the mechanism underlying the long-term decline of serviceable hearing; however, the deterioration of PTA in the early postoperative period may help to predict the long-term outcomes of hearing.
尽管许多研究者报告了前庭神经鞘瘤(VS)患者术后即刻的听力功能,但对于术后听力的长期预后却知之甚少。本研究的目的是分析采用乙状窦后入路治疗的单侧VS患者在平均5年随访期的长期听力预后。本研究纳入了24例术后即刻听力可用且接受了多次听力图检查或电话访谈的患者。在平均随访期(68.8±30.2个月,范围14 - 123个月)内,24例患者中有20例(83%)的可用听力得以保留。7例患者在6个月内重新评估了纯音平均听阈(PTA)。在术后6个月内PTA恶化≥5 dB的2例患者中,与术后即刻的PTA相比,其PTA恶化≥15 dB。在术后6个月内PTA恶化<5 dB的其余5例患者中,最终随访时PTA维持在恶化15 dB以内(p = 0.04,Fisher精确检验)。根据Kaplan-Meier生存曲线,可用听力的5年或7年保留率分别为86.2%或71.8%。需要进一步研究以阐明可用听力长期下降的潜在机制;然而,术后早期PTA的恶化可能有助于预测听力的长期预后。