果蝇眼柄发育中组织特异性 Jak/STAT 靶基因的证据。
Evidence for tissue-specific Jak/STAT target genes in Drosophila optic lobe development.
机构信息
School of Life Sciences, Tsinghua University, Beijing 100084, China.
出版信息
Genetics. 2013 Dec;195(4):1291-306. doi: 10.1534/genetics.113.155945. Epub 2013 Sep 27.
Abstract
The evolutionarily conserved JAK/STAT pathway plays important roles in development and disease processes in humans. Although the signaling process has been well established, we know relatively little about what the relevant target genes are that mediate JAK/STAT activation during development. Here, we have used genome-wide microarrays to identify JAK/STAT targets in the optic lobes of the Drosophila brain and identified 47 genes that are positively regulated by JAK/STAT. About two-thirds of the genes encode proteins that have orthologs in humans. The STAT targets in the optic lobe appear to be different from the targets identified in other tissues, suggesting that JAK/STAT signaling may regulate different target genes in a tissue-specific manner. Functional analysis of Nop56, a cell-autonomous STAT target, revealed an essential role for this gene in the growth and proliferation of neuroepithelial stem cells in the optic lobe and an inhibitory role in lamina neurogenesis.
摘要
进化保守的 JAK/STAT 途径在人类的发育和疾病过程中发挥着重要作用。尽管信号转导过程已经得到很好的建立，但我们相对较少了解在发育过程中介导 JAK/STAT 激活的相关靶基因是什么。在这里，我们使用全基因组微阵列鉴定了果蝇大脑视神经叶中的 JAK/STAT 靶标，并鉴定了 47 个受 JAK/STAT 正向调控的基因。大约三分之二的基因编码在人类中具有同源物的蛋白质。视神经叶中的 STAT 靶标似乎与在其他组织中鉴定的靶标不同，这表明 JAK/STAT 信号可能以组织特异性的方式调节不同的靶基因。对 Nop56（一种细胞自主的 STAT 靶标）的功能分析表明，该基因在视神经叶中的神经上皮干细胞的生长和增殖中起着至关重要的作用，并且在板层神经发生中起着抑制作用。
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