NOP56 在癌症和 SCA36 中的作用。
The roles of NOP56 in cancer and SCA36.
机构信息
Department of General Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Jiangxi Province Key Laboratory of Molecular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
出版信息
Pathol Oncol Res. 2023 Jan 19;29:1610884. doi: 10.3389/pore.2023.1610884. eCollection 2023.
NOP56 is a highly conserved nucleolar protein. Amplification of the intron GGCCTG hexanucleotide repeat sequence of the gene results in spinal cerebellar ataxia type 36 (SCA36). NOP56 contains an N-terminal domain, a coiled-coil domain, and a C-terminal domain. Nucleolar protein NOP56 is significantly abnormally expressed in a number of malignant tumors, and its mechanism is different in different tumors, but its regulatory mechanism in most tumors has not been fully explored. NOP56 promotes tumorigenesis in some cancers and inhibits tumorigenesis in others. In addition, NOP56 is associated with methylation in some tumors, suggesting that NOP56 has the potential to become a tumor-specific marker. This review focuses on the structure, function, related signaling pathways, and role of NOP56 in the progression of various malignancies, and discusses the progression of NOP56 in neurodegenerative and other diseases.
NOP56 是一种高度保守的核仁蛋白。基因的内含子 GGCCTG 六核苷酸重复序列的扩增导致脊髓小脑共济失调 36 型（SCA36）。NOP56 包含一个 N 端结构域、一个卷曲螺旋结构域和一个 C 端结构域。核仁蛋白 NOP56 在许多恶性肿瘤中表达明显异常，其机制在不同肿瘤中不同，但在大多数肿瘤中的调节机制尚未完全探索。NOP56 在一些癌症中促进肿瘤发生，而在另一些癌症中抑制肿瘤发生。此外，NOP56 与一些肿瘤中的甲基化有关，这表明 NOP56 有可能成为肿瘤特异性标志物。本综述重点介绍了 NOP56 在各种恶性肿瘤中的结构、功能、相关信号通路以及在肿瘤进展中的作用，并讨论了 NOP56 在神经退行性疾病和其他疾病中的进展。
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