Forzán M J, Garde E, Pérez G E, Vanderstichel R V
Canadian Cooperative Wildlife Health Centre, Department of Pathology and Microbiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PE, Canada
Veterinarians without Borders/Veterinarios sin Fronteras-Canada, Latin America Regional Office, Valdivia, Chile.
Vet Pathol. 2014 Jul;51(4):820-3. doi: 10.1177/0300985813505875. Epub 2013 Sep 27.
Intratesticular injection of EsterilSol (zinc gluconate neutralized with arginine) is a chemical sterilant for male dogs sometimes used in population control campaigns. Adverse reactions have been reported in 1% to 4% of treated dogs, but detailed histomorphologic descriptions are lacking. During a behavioral study conducted in the Chilean Patagonia in 2012, severe necrosuppurative orchitis and ulcerative dermatitis were observed in 2 of 36 (6%) dogs sterilized with EsterilSol according to the manufacturer's instructions. Reactions were noted on days 8 and 7 postinjection and required scrotal ablation on days 8 and 13, respectively; neither reaction was associated with the injection site. Although self-trauma following administration may have contributed, the cause of the adverse reactions is uncertain. EsterilSol is a relatively uncomplicated method to sterilize male dogs, but the occurrence of severe adverse reactions several days after administration emphasizes the need for the provision of long-term monitoring and veterinary care during sterilization campaigns using this product.
睾丸内注射EsterilSol（用精氨酸中和的葡萄糖酸锌）是一种用于雄性犬的化学绝育剂，有时用于种群控制活动。据报道，1%至4%的接受治疗的犬出现了不良反应，但缺乏详细的组织形态学描述。在2012年于智利巴塔哥尼亚进行的一项行为研究中，按照制造商的说明用EsterilSol绝育的36只犬中有2只（6%）出现了严重的坏死性化脓性睾丸炎和溃疡性皮炎。反应分别在注射后第8天和第7天被注意到，分别在第8天和第13天需要进行阴囊切除；两种反应均与注射部位无关。尽管给药后自我创伤可能起到了一定作用，但不良反应的原因尚不确定。EsterilSol是一种相对简单的雄性犬绝育方法，但给药几天后出现严重不良反应强调了在使用该产品的绝育活动期间提供长期监测和兽医护理的必要性。
