Lane S B, Bunch S E
Department of Companion Animal and Special Species Medicine, College of Veterinary Medicine, North Carolina State University, Raleigh 27606.
J Vet Intern Med. 1990 Jan-Feb;4(1):26-39. doi: 10.1111/j.1939-1676.1990.tb00871.x.
The problem of recurrent seizures is a common and challenging one in veterinary medical practice. The pathophysiology and pharmacologic suppression of focal seizure activity have been studied extensively in basic research settings, yet little is known of the genesis, modulation, and termination of generalized seizures, the most common form of seizures noted to occur in companion animals. Knowledge concerning the pharmacokinetic fate of anticonvulsant drugs currently used in veterinary medicine is adequate, though prospective clinical studies of the efficacy of these drugs in the treatment of various types of seizures are lacking. This study will review the available literature regarding the pharmacology, use, and side effects of anticonvulsant drugs currently available for control of recurrent seizures in companion animals. Alternative anticonvulsant drugs will also be described.
在兽医临床实践中，癫痫反复发作是一个常见且具有挑战性的问题。在基础研究环境中，已经对局灶性癫痫发作活动的病理生理学和药物抑制进行了广泛研究，但对于全身性癫痫发作（伴侣动物中最常见的癫痫发作形式）的发生、调节和终止却知之甚少。目前兽医医学中使用的抗惊厥药物的药代动力学转归已有足够了解，不过缺乏关于这些药物治疗各种类型癫痫发作疗效的前瞻性临床研究。本研究将综述有关目前可用于控制伴侣动物癫痫反复发作的抗惊厥药物的药理学、用途和副作用的现有文献。还将描述替代抗惊厥药物。
