Arch Pharm Res. 2014 Jul;37(7):839-44. doi: 10.1007/s12272-013-0246-8.
Chemical investigation of an Antarctic deepsea derived fungus Penicillium sp. PR19 N-1 yielded five new eremophilane-type sesquiterpenes 1–5 and a new rare lactam-type eremophilane 6, together with three known compounds 7–9. The structures of these diverse sesquiterpenes were determined by extensive NMR and mass spectroscopic analyses. Compounds 1, 2, 4–6, 8 and 9 were evaluated for their cytotoxities against HL-60 and A-549 human cancer cell lines, and 5 was the most active one with IC50 value of 5.2 lM against the A-549 cells.
从南极深海真菌 Penicillium sp. PR19 N-1 中分离得到的化学成分研究得到了五个新的厄尔门烷型倍半萜 1-5 和一个新的罕见的内酰胺型厄尔门烷 6，以及三个已知化合物 7-9。这些不同的倍半萜的结构通过广泛的 NMR 和质谱分析确定。化合物 1、2、4-6、8 和 9 被评估对 HL-60 和 A-549 人癌细胞系的细胞毒性，化合物 5 对 A-549 细胞的 IC50 值为 5.2 lM，是最具活性的一个。
