异常瘢痕形成模型。
Models of abnormal scarring.
机构信息
Department of Plastic and Reconstructive Surgery, Uijeongbu St. Mary's Hospital, College of Medicine, Catholic University of Korea, 65-1 Kumoh-Dong, Uijeongbu 480-135, Republic of Korea.
出版信息
Biomed Res Int. 2013;2013:423147. doi: 10.1155/2013/423147. Epub 2013 Sep 3.
Abstract
Keloids and hypertrophic scars are thick, raised dermal scars, caused by derailing of the normal scarring process. Extensive research on such abnormal scarring has been done; however, these being refractory disorders specific to humans, it has been difficult to establish a universal animal model. A wide variety of animal models have been used. These include the athymic mouse, rats, rabbits, and pigs. Although these models have provided valuable insight into abnormal scarring, there is currently still no ideal model. This paper reviews the models that have been developed.
摘要
瘢痕疙瘩和增生性瘢痕是由正常瘢痕形成过程脱轨引起的厚的、隆起的皮肤瘢痕。已经对这种异常瘢痕进行了广泛的研究；然而，由于这些是人类特有的难治性疾病，因此很难建立通用的动物模型。已经使用了各种各样的动物模型。这些模型包括无胸腺小鼠、大鼠、兔子和猪。尽管这些模型为异常瘢痕的形成提供了有价值的见解，但目前仍然没有理想的模型。本文综述了已经开发的模型。
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J Dermatol. 2013 May;40(5):380-3. doi: 10.1111/1346-8138.12116. Epub 2013 Mar 4.
2
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3
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