Japan Science and Technology Agency, CREST, Tokyo, Japan.
Exp Dermatol. 2013 Oct;22(10):662-4. doi: 10.1111/exd.12224.
Dry environmental conditions induce a variety of skin pathologies and a recent report indicating that cortisol synthesis in epidermis was increased during wound healing led us to hypothesize that environmental dryness might induce increased cortisol secretion in epidermis. Therefore, we incubated a skin equivalent model under dry (relative humidity: less than 10%) and humid (relative humidity: approximately 100%) conditions for 48 hours and evaluated cortisol secretion and mRNA levels of cortisol-synthesizing enzyme (steroid 11β-hydroxylase, CYP11B1) and IL-1β. Cortisol secretion was increased threefold, and CYP11B1 and IL-1β mRNAs were increased 38-fold and sixfold, respectively, in the dry condition versus the humid condition. Occlusion with a water-impermeable plastic membrane partially blocked the increases in cortisol secretion and CYP11B1 and IL-1β mRNA expression in the dry condition. Thus, environmental dryness might induce increased cortisol secretion in epidermis of diseased skin characterized by epidermal barrier dysfunction, potentially influencing mental state and systemic physiology.
干燥的环境条件会引起多种皮肤病理，最近有报道表明，在伤口愈合过程中表皮中的皮质醇合成增加，这使我们假设环境干燥可能会导致表皮中皮质醇分泌增加。因此，我们将皮肤等效模型在干燥（相对湿度：小于 10%）和潮湿（相对湿度：约 100%）条件下孵育 48 小时，并评估皮质醇分泌以及皮质醇合成酶（类固醇 11β-羟化酶，CYP11B1）和 IL-1β 的 mRNA 水平。与潮湿条件相比，干燥条件下皮质醇分泌增加了三倍，CYP11B1 和 IL-1β 的 mRNA 分别增加了 38 倍和 6 倍。用不透水的塑料膜封闭可部分阻止干燥条件下皮质醇分泌以及 CYP11B1 和 IL-1β mRNA 表达的增加。因此，环境干燥可能会导致表皮屏障功能障碍的疾病皮肤中的皮质醇分泌增加，这可能会影响精神状态和全身生理学。
