Zhu Guo, Janjetovic Zorica, Slominski Andrzej
Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
Exp Dermatol. 2014 Jan;23(1):15-7. doi: 10.1111/exd.12275.
Evidence is accumulating that skin can act as an independent steroidogenic organ. It can respond to various stresses including UV light, trauma and oncogenesis by upregulating glucocorticoid production via elements of the local hypothalamic-pituitary-adrenal (HPA) axis. Recent data by Takei and collaborators provided in this issue of Experimental Dermatology included dryness to the list of stressors stimulating cutaneous cortisol synthesis with a possible involvement of IL-1β as a mediator of this regulation. Thus, the last decade of research has not only documented that skin can produce cortisol, but that levels of its production change in response to environmental stress. The role of this regulated steroidogenic system in physiological or pathological outcomes requires further studies with focus on cutaneous homeostasis, formation of epidermal barrier, antimicrobial activity and display of immune (both pro- and anti-inflammatory) properties.
越来越多的证据表明，皮肤可作为一个独立的类固醇生成器官。它能够通过局部下丘脑 - 垂体 - 肾上腺（HPA）轴的元件上调糖皮质激素的产生，来应对包括紫外线、创伤和肿瘤发生在内的各种应激。竹井及其合作者在本期《实验皮肤病学》上提供的最新数据，将皮肤干燥列入刺激皮肤皮质醇合成的应激源清单，白细胞介素 -1β 可能作为这种调节的介质参与其中。因此，过去十年的研究不仅证明皮肤能够产生皮质醇，而且其产生水平会随着环境应激而变化。这种受调节的类固醇生成系统在生理或病理结果中的作用，需要进一步聚焦于皮肤稳态、表皮屏障形成、抗菌活性以及免疫（促炎和抗炎）特性表现的研究。
