Unit of Cognitive Frailty, MedCampus Hohenlind, Werthmannstr. 1c, 50935 Koln.
Curr Pharm Des. 2014;20(18):3083-92. doi: 10.2174/13816128113196660706.
Alzheimer's Disease (AD) is a progressive neurodegenerative disorder representing the most common form of dementia and the most feared highly disabling age-related condition of our time. Hallmarks of AD include a dramatically increasing number of cases due to prospected demographics and the absence of a cure. AD is incurable as it escapes the formula "one disease, one mechanism, one drug". AD has a multifaceted pathophysiology only in part uncovered. Even the proven chronological primacy of free radical-related damage in AD-related neurodegeneration has not yield successful oxidative stress - lowering trial designs. As a consequence, clinical trials of antioxidants in AD have brought largely negative conclusions. The aims of this review are to discuss 1. rationale for antioxidant trials, 2. reasons for failure of antioxidants in AD therapy, 3. potential preventive benefits of natural nutrition against AD onset and 4. the enormous relevance of detecting and treating AD risk factors as long as possible prior to AD manifestation.
阿尔茨海默病（AD）是一种进行性神经退行性疾病，是最常见的痴呆症形式，也是当前人们最害怕的高度致残的与年龄相关的疾病。AD 的标志包括由于预期的人口统计学和缺乏治愈方法导致的病例数量急剧增加。AD 是无法治愈的，因为它避开了“一种疾病，一种机制，一种药物”的公式。AD 的病理生理学具有多方面的特点，目前只揭示了一部分。即使是自由基相关损伤在 AD 相关神经退行性变中的时间顺序优势也没有产生成功的降低氧化应激的试验设计。因此，AD 抗氧化剂的临床试验得出的结论大多是负面的。本综述的目的是讨论 1. 抗氧化剂试验的基本原理，2. 抗氧化剂在 AD 治疗中失败的原因，3. 天然营养对 AD 发病的潜在预防作用，4. 在 AD 表现之前尽可能早地发现和治疗 AD 危险因素的巨大相关性。
