Beran A V, Proctor K G, Sperling D R
J Appl Physiol. 1975 Aug;39(2):337-40. doi: 10.1152/jappl.1975.39.2.337.
Hypothermia and rewarming were induced by a combination of temperature-controlled surface and inhalate methods in rabbits. To facilitate respiratory heat exchange, inhalate-respiratory tract temperature and humidity gradients and thermal conductivity were increased. In addition, the upper respiratory tract was bypassed by an endotracheal tube. To aid in maintaining satisfactory circulatory dynamics, hypercapnia and hypoxia were induced. The combined surface and inhalate method produced a markedly more effective rate of cooling than surface temperature-controlled method alone. Animals survived core temperatures as low as 20.9 degrees C with no complications. The noninvasive simplicity of this method suggests its potential applicability in many clinical situations.
通过温度控制表面和吸入方法相结合的方式在兔子身上诱导体温过低和复温。为促进呼吸热交换，提高了吸入物与呼吸道的温度和湿度梯度以及热导率。此外，通过气管内导管绕过了上呼吸道。为有助于维持令人满意的循环动力学，诱导了高碳酸血症和低氧血症。与单独的表面温度控制方法相比，表面和吸入相结合的方法产生了明显更有效的降温速率。动物在核心体温低至20.9摄氏度时存活且无并发症。这种方法的非侵入性简单性表明其在许多临床情况下具有潜在的适用性。
