中度高碳酸血症对大鼠冷氦氧混合气诱导低温的影响。

Effects of moderate hypercapnia on hypothermia induced by cold He-O2 in rats.

Morita T, Konaka K, Kawasaki Y, Kawai F, Kanamori M, Mitsuda H

Interdisciplinary Research Institute of Environmental Sciences, Kyoto, Japan.

Comp Biochem Physiol Comp Physiol. 1993 Feb;104(2):215-8. doi: 10.1016/0300-9629(93)90305-n.

Abstract

Effects of moderate hypercapnia (10% CO2) on rectal temperature, oxygen consumption and body weight loss were examined during and after acute hypothermia induced by cold and helium-oxygen. 2. Hypothermia induction time was reduced significantly by hypercapnia. Rewarming tended to be faster in hypercapnic animals than in normocapnic animals. 3. Hypercapnia significantly reduced body weight loss when measured during hypothermia and during normothermia after rewarming. 4. Oxygen consumption during cooling was decreased by hypercapnia. 5. Exposure to 10% CO2 during cooling may spare energy substrate and favor survival in hypothermia.

摘要

研究了中度高碳酸血症（10%二氧化碳）对冷诱导及氦氧诱导急性低温期间和之后直肠温度、耗氧量和体重减轻的影响。2. 高碳酸血症显著缩短了低温诱导时间。与正常碳酸血症动物相比，高碳酸血症动物的复温往往更快。3. 高碳酸血症显著减轻了低温期间及复温后正常体温期间测量的体重减轻。4. 降温期间高碳酸血症降低了耗氧量。5. 降温期间暴露于10%二氧化碳可能节省能量底物并有利于低温下的存活。