Bartuzi Paulina, Hofker Marten H, van de Sluis Bart
University of Groningen, University Medical Center Groningen, Molecular Genetics, Antonius Deusinglaan 1, 9713AV Groningen, The Netherlands.
Biochim Biophys Acta. 2013 Dec;1832(12):2315-21. doi: 10.1016/j.bbadis.2013.09.014. Epub 2013 Sep 29.
NF-κB is an important regulator of immunity and inflammation, and its activation pathway has been studied extensively. The mechanisms that downregulate the activity of NF-κB have also received a lot of attention, particularly since its activity needs to be terminated to prevent chronic inflammation and subsequent tissue damage. The COMMD family has been identified as a new group of proteins involved in NF-κB termination. All ten COMMD members share the structurally conserved carboxy-terminal motif, the COMM domain, and are ubiquitously expressed. They seem to play distinct and non-redundant roles in various physiological processes, including NF-κB signaling. In this review, we describe the mechanisms and proteins involved in the termination of canonical NF-κB signaling, with a specific focus on the role of the COMMD family in the down-modulation of NF-κB.
核因子κB（NF-κB）是免疫和炎症的重要调节因子，其激活途径已得到广泛研究。下调NF-κB活性的机制也受到了很多关注，特别是因为需要终止其活性以预防慢性炎症及随后的组织损伤。COMMD家族已被确定为参与NF-κB终止的一组新蛋白质。COMMD家族的所有十个成员都具有结构保守的羧基末端基序即COMM结构域，并且在全身广泛表达。它们似乎在包括NF-κB信号传导在内的各种生理过程中发挥着独特且不可替代的作用。在本综述中，我们描述了经典NF-κB信号传导终止所涉及的机制和蛋白质，特别关注COMMD家族在NF-κB下调中的作用。
