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2
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LINE-1 ORF-1p functions as a novel HGF/ETS-1 signaling pathway co-activator and promotes the growth of MDA-MB-231 cell.LINE-1开放阅读框1蛋白作为一种新型的肝细胞生长因子/ETS-1信号通路共激活因子，促进MDA-MB-231细胞的生长。
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Denervation drives skeletal muscle atrophy and induces mitochondrial dysfunction, mitophagy and apoptosis via miR-142a-5p/MFN1 axis.去神经支配导致骨骼肌萎缩，并通过 miR-142a-5p/MFN1 轴诱导线粒体功能障碍、自噬和细胞凋亡。
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Macrophage polarization as a novel weapon in conditioning tumor microenvironment for bladder cancer: can we turn demons into gods?巨噬细胞极化作为一种新型手段调节膀胱癌肿瘤微环境：我们能否化腐朽为神奇？
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CREB1-driven expression of miR-320a promotes mitophagy by down-regulating VDAC1 expression during serum starvation in cervical cancer cells.在血清饥饿条件下，CREB1驱动的miR-320a表达通过下调宫颈癌细胞中的VDAC1表达来促进线粒体自噬。
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miR-155 Is Essential for Inflammation-Induced Hippocampal Neurogenic Dysfunction.miR-155对炎症诱导的海马神经发生功能障碍至关重要。
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10
Epigenetic silencing of microRNA-149 in cancer-associated fibroblasts mediates prostaglandin E2/interleukin-6 signaling in the tumor microenvironment.癌症相关成纤维细胞中微小RNA-149的表观遗传沉默介导肿瘤微环境中的前列腺素E2/白细胞介素-6信号传导。
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本文引用的文献

1
A novel miR-155/miR-143 cascade controls glycolysis by regulating hexokinase 2 in breast cancer cells.一种新型的 miR-155/miR-143 级联通过调节乳腺癌细胞中的己糖激酶 2 来控制糖酵解。
EMBO J. 2012 Apr 18;31(8):1985-98. doi: 10.1038/emboj.2012.45. Epub 2012 Feb 21.
2
Targeting microRNAs in cancer: rationale, strategies and challenges.靶向癌症中的 microRNAs：原理、策略和挑战。
Nat Rev Drug Discov. 2010 Oct;9(10):775-89. doi: 10.1038/nrd3179.
3
MicroRNA-155 functions as an OncomiR in breast cancer by targeting the suppressor of cytokine signaling 1 gene.MicroRNA-155 在乳腺癌中作为一种癌基因发挥作用，其靶基因是细胞因子信号转导抑制因子 1。
Cancer Res. 2010 Apr 15;70(8):3119-27. doi: 10.1158/0008-5472.CAN-09-4250. Epub 2010 Mar 30.
4
Immunity, inflammation, and cancer.免疫、炎症与癌症。
Cell. 2010 Mar 19;140(6):883-99. doi: 10.1016/j.cell.2010.01.025.
5
Inflammation and cancer: interweaving microRNA, free radical, cytokine and p53 pathways.炎症与癌症：miRNA、自由基、细胞因子与 p53 通路的交织。
Carcinogenesis. 2010 Jan;31(1):37-49. doi: 10.1093/carcin/bgp272. Epub 2009 Dec 2.
6
miR-155: on the crosstalk between inflammation and cancer.微小RNA-155：炎症与癌症之间的相互作用
Int Rev Immunol. 2009;28(5):264-84. doi: 10.1080/08830180903093796.
7
MicroRNA and cancer--focus on apoptosis.微小RNA与癌症——聚焦于细胞凋亡
J Cell Mol Med. 2009 Jan;13(1):12-23. doi: 10.1111/j.1582-4934.2008.00510.x.
8
MicroRNA 155 modulates megakaryopoiesis at progenitor and precursor level by targeting Ets-1 and Meis1 transcription factors.微小RNA 155通过靶向Ets-1和Meis1转录因子在祖细胞和前体细胞水平调节巨核细胞生成。
Br J Haematol. 2008 Nov;143(4):570-80. doi: 10.1111/j.1365-2141.2008.07382.x.
9
The TRANSFAC system on gene expression regulation.关于基因表达调控的TRANSFAC系统。
Nucleic Acids Res. 2001 Jan 1;29(1):281-3. doi: 10.1093/nar/29.1.281.

MicroRNA-155 broadly orchestrates inflammation-induced changes of microRNA expression in breast cancer.

作者信息

Hu Song, Zhu Wei, Zhang Ling-Fei, Pei Ming, Liu Mo-Fang

机构信息

1] Center for RNA Research, State Key Laboratory of Molecular Biology, University of Chinese Academy of Sciences, Shanghai 200031, China [2] Shanghai Key Laboratory of Molecular Andrology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

出版信息

Cell Res. 2014 Feb;24(2):254-7. doi: 10.1038/cr.2013.137. Epub 2013 Oct 1.

DOI:10.1038/cr.2013.137
PMID:24080728
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3915901/
Abstract
摘要