Reid F, Henry J A
National Poisons Information Service, Guy's Hospital, London, United Kingdom.
Pharmacopsychiatry. 1990 Jan;23 Suppl 1:23-7. doi: 10.1055/s-2007-1014526.
Data presented show that lofepramine has lower acute toxicity for animals than other antidepressants tested. Review of 55 case reports of acute lofepramine overdose in man shows that hypotension was rare and convulsions did not occur, although in some cases large overdoses of several grams of drug had been taken. No deaths have been recorded due to overdose with lofepramine alone, and the fatal toxicity index for lofepramine (deaths per million prescriptions, England, Wales and Scotland, 1982-1986) is significantly lower than the mean of all antidepressants (P less than 0.001). It thus appears that the low toxicity of lofepramine in animal experiments applies also to man, and that this drug has a favourable safety profile when taken in acute overdose.
所呈现的数据表明，洛非帕明对动物的急性毒性低于所测试的其他抗抑郁药。对55例人类急性洛非帕明过量病例报告的回顾显示，低血压罕见，且未发生惊厥，尽管在某些病例中服用了数克的大剂量药物。尚无仅因洛非帕明过量而导致死亡的记录，洛非帕明的致死毒性指数（1982 - 1986年英格兰、威尔士和苏格兰每百万张处方的死亡数）显著低于所有抗抑郁药的平均值（P小于0.001）。因此，洛非帕明在动物实验中的低毒性似乎也适用于人类，并且该药物在急性过量服用时具有良好的安全性。
