Sgouros Dimitris, Piana Simonetta, Argenziano Giuseppe, Longo Caterina, Moscarella Elvira, Karaarslan Isil Kilinc, Akalin Taner, Ozdemir Fezal, Zalaudek Iris
2nd Department of Dermatology, Athens University School of Medicine, Attikon General University Hospital, Athens, Greece.
Dermatology. 2013;227(2):175-9. doi: 10.1159/000354152. Epub 2013 Sep 24.
Eccrine poroma (EP) belongs to the group of benign adnexal tumors, but cases of eccrine porocarcinoma (EPC) arising on long-standing and untreated EP suggest a certain risk of malignant transformation.
To describe the clinical, dermoscopic and histopathologic features associated with different extremes in the spectrum of eccrine poroid neoplasms and to review the according literature.
A retrospective analysis of patient characteristics and morphologic features associated with EP, EPC in situ and invasive porocarcinoma patients who attended two skin lesion clinics in Italy and Turkey between 2010 and 2011.
A total of 4 cases including 1 EP, 1 EPC in situ and 2 cases of invasive EPC in 4 patients were analyzed. Recent changes including bleeding, ulceration and sudden enlargement of a pre-existing lesion were associated with malignant transformation. Dermoscopically, polymorphous vessels consisting of coiled, hairpin and linear vessels were seen at all stages of progression. Histopathological findings of EPC in situ were limited to the epidermal component and were evident only at higher magnification.
Clinicians and pathologists should carefully evaluate EPs with a recent history of change and erosion in order to avoid overlooking the potential development of EPC.
小汗腺汗孔瘤（EP）属于良性附属器肿瘤，但长期未治疗的EP发生小汗腺汗孔癌（EPC）的病例提示存在一定的恶变风险。
描述与小汗腺汗孔样肿瘤谱系中不同极端情况相关的临床、皮肤镜和组织病理学特征，并复习相关文献。
对2010年至2011年期间在意大利和土耳其两家皮肤病变诊所就诊的EP、原位EPC和浸润性汗孔癌患者的患者特征和形态学特征进行回顾性分析。
共分析了4例患者的4个病例，包括1例EP、1例原位EPC和2例浸润性EPC。近期出现的变化，如出血、溃疡和原有病变突然增大，与恶变有关。在皮肤镜下，在疾病进展的各个阶段均可见由盘绕状、发夹状和线状血管组成的多形性血管。原位EPC的组织病理学表现局限于表皮成分，仅在高倍镜下可见。
临床医生和病理学家应仔细评估近期有变化和糜烂史的EP，以避免忽视EPC的潜在发展。
