Johansen K
Department of Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh.
Ugeskr Laeger. 1990 Feb 26;152(9):584-8.
Atherosclerosis is the most prevalent long-term diabetic complication. The increased mortality and morbidity in diabetics caused by atherosclerosis has been related to the frequent occurrence of hyperlipidaemia in diabetes. Insulin regulates many processes in lipid metabolism via control of enzyme activity and receptor binding. It is important to establish a precise diagnosis of the lipid abnormalities before commencing treatment. The treatment begins with control of blood glucose, followed by dietary treatment of hyperlipidaemia. Hypolipidaemic drugs are first introduced when the dietary response is unsatisfactory. Optimal therapy with antidiabetic drugs should precede hypolipidaemic drug therapy.
动脉粥样硬化是最常见的糖尿病长期并发症。动脉粥样硬化导致糖尿病患者死亡率和发病率增加，这与糖尿病中高脂血症的频繁发生有关。胰岛素通过控制酶活性和受体结合来调节脂质代谢的许多过程。在开始治疗之前，准确诊断脂质异常很重要。治疗首先要控制血糖，然后对高脂血症进行饮食治疗。当饮食治疗效果不理想时，首先使用降血脂药物。降血脂药物治疗应在抗糖尿病药物的最佳治疗之后进行。
