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Changes of very low-density lipoprotein concentration in hepatic blood from cows with fasting-induced hepatic lipidosis.禁食诱导的奶牛肝脏脂质osis时肝脏血液中极低密度脂蛋白浓度的变化。
Can J Vet Res. 2010 Oct;74(4):317-20.
2
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Mol Vis. 2007 Oct 29;13:2041-7.
3
Recent advances in vitamin E metabolism and deficiency.维生素E代谢与缺乏症的最新进展。
Eur J Pediatr. 2006 Jul;165(7):429-34. doi: 10.1007/s00431-006-0084-5. Epub 2006 Feb 21.
4
Role of the actin cytoskeleton during respiratory burst in chemoattractant-stimulated neutrophils.肌动蛋白细胞骨架在趋化因子刺激的中性粒细胞呼吸爆发过程中的作用。
Cell Biol Int. 2006 Feb;30(2):154-63. doi: 10.1016/j.cellbi.2005.10.017. Epub 2006 Jan 30.
5
Comparative effects of RRR-alpha- and RRR-gamma-tocopherol on proliferation and apoptosis in human colon cancer cell lines.RRR-α-生育酚和RRR-γ-生育酚对人结肠癌细胞系增殖和凋亡的比较作用
BMC Cancer. 2006 Jan 17;6:13. doi: 10.1186/1471-2407-6-13.
6
Scavenger receptor class B type I (SR-BI) is involved in vitamin E transport across the enterocyte.I型清道夫受体B类（SR-BI）参与维生素E跨肠细胞的转运。
J Biol Chem. 2006 Feb 24;281(8):4739-45. doi: 10.1074/jbc.M509042200. Epub 2005 Dec 27.
7
Internalization and phagosome escape required for Francisella to induce human monocyte IL-1beta processing and release.弗朗西斯菌诱导人单核细胞IL-1β加工和释放所需的内化和吞噬体逃逸。
Proc Natl Acad Sci U S A. 2006 Jan 3;103(1):141-6. doi: 10.1073/pnas.0504271103. Epub 2005 Dec 22.
8
Role of the actin cytoskeleton in T cell absorption and internalization of ligands from APC.肌动蛋白细胞骨架在T细胞从抗原呈递细胞吸收和内化配体中的作用。
J Immunol. 2001 Apr 15;166(8):5099-107. doi: 10.4049/jimmunol.166.8.5099.
9
Dietary vitamin A modulates the concentrations of RRR-alpha-tocopherol in plasma lipoproteins from calves fed milk replacer.日粮维生素A可调节饲喂代乳粉犊牛血浆脂蛋白中RRR-α-生育酚的浓度。
J Nutr. 2000 Mar;130(3):629-36. doi: 10.1093/jn/130.3.629.
10
Effects of vitamins A and E on superoxide production and intracellular signaling of neutrophils in Holstein calves.维生素A和维生素E对荷斯坦犊牛中性粒细胞超氧化物生成及细胞内信号传导的影响。
Can J Vet Res. 2000 Jan;64(1):69-75.

维生素E补充剂对荷斯坦犊牛中性粒细胞中细胞α-生育酚浓度的影响。

Effects of vitamin E supplementation on cellular α-tocopherol concentrations of neutrophils in Holstein calves.

作者信息

Higuchi Hidetoshi, Ito Erina, Iwano Hidetoma, Oikawa Shin, Nagahata Hajime

机构信息

Animal Health Laboratory (Higuchi, Ito, Nagahata), Department of Veterinary Herd Health (Oikawa), Department of Health and Environmental Sciences and Veterinary Biochemistry, and Department of Bioscience (Iwano), School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan.

出版信息

Can J Vet Res. 2013 Apr;77(2):120-5.

PMID:24082403
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3605927/
Abstract

The effects of vitamin E supplementation on cellular α-tocopherol concentrations of neutrophils from Holstein calves and the mechanism of scavenger receptor class B type I (SR-BI)-mediated uptake of α-tocopherol were examined. Cellular α-tocopherol concentrations in vitamin E-treated calves increased from 3.5 ± 0.38 to 7.2 ± 0.84 μg/10(7) cells, respectively, within 14 d after vitamin E supplementation; these concentrations were significantly higher than those of control calves (P < 0.01). The expression indices of SR-BI [a major receptor that recognizes high-density lipoprotein (HDL)] mRNA in neutrophils were two to five times higher (P < 0.01) in neutrophils obtained from vitamin E-supplemented calves compared with those from control calves, and anti-SR-B1 antibody, ranging from 0.1 to 1.0 μg/mL, significantly (P < 0.01) decreased cellular α-tocopherol concentrations of neutrophils. Cytochalasin D and latrunculin B, major inhibitors of actin polymerization of neutrophils, significantly decreased cellular α-tocopherol concentrations of neutrophils (P < 0.01). Our results demonstrated that in vitamin E-supplemented calves: 1) α-tocopherol is mainly distributed with HDL, 2) α-tocopherol within HDL is recognized by SR-BI on the surface of neutrophils, and 3) rearrangement of the actin cytoskeleton is a crucial step for the uptake of α-tocopherol by neutrophils.

摘要

研究了补充维生素E对荷斯坦犊牛中性粒细胞中细胞α-生育酚浓度的影响以及I型清道夫受体（SR-BI）介导的α-生育酚摄取机制。补充维生素E后14天内，维生素E处理的犊牛细胞α-生育酚浓度分别从3.5±0.38μg/10⁷细胞增加到7.2±0.84μg/10⁷细胞；这些浓度显著高于对照犊牛（P<0.01）。与对照犊牛相比，补充维生素E的犊牛中性粒细胞中SR-BI（一种识别高密度脂蛋白（HDL）的主要受体）mRNA的表达指数高2至5倍（P<0.01），浓度范围为0.1至1.0μg/mL的抗SR-B1抗体显著降低了中性粒细胞的细胞α-生育酚浓度（P<0.01）。细胞松弛素D和拉特罗毒素B是中性粒细胞肌动蛋白聚合的主要抑制剂，显著降低了中性粒细胞的细胞α-生育酚浓度（P<0.01）。我们的结果表明，在补充维生素E的犊牛中：1）α-生育酚主要与HDL一起分布，2）HDL中的α-生育酚被中性粒细胞表面的SR-BI识别，3）肌动蛋白细胞骨架的重排是中性粒细胞摄取α-生育酚的关键步骤。