Borgohain Mondita, Gogoi Gayatri, Das Dipak, Biswas Manjusha
Department of Pathology, Assam Medical College and Hospital, Dibrugarh, Assam, India.
Indian J Endocrinol Metab. 2013 Sep;17(5):917-9. doi: 10.4103/2230-8210.117217.
Paragangliomas are rare neuroendocrine neoplasms arising in extra-adrenal chromaffin cells of autonomic nervous system and histologically akin to chemodectomas. They are rare, affecting about 1 in 2,000,000 population. It is a generic term applied to tumors of paraganglia regardless of the location. In rare instances, paragangliomas present around and involve the pancreas, thereby mimicking any one of the more common primary pancreatic lesions. Pancreatic paraganglioma is an extremely rare tumor. It grows slowly, so radical resection is recommended to achieve curability with good prognosis. These neoplasms present considerable diagnostic difficulty not only for the clinician and radiologist but also for the pathologist. Here, we report a case of a 55-year-old woman who presented with a left-sided abdominal swelling for 3 months duration, initially having clinical suspicion of an ovarian tumor. The radiological imaging revealed a lesion in the tail of pancreas with a differential diagnosis of pancreatic carcinoma and metastatic tumor. Only after exploratory laparotomy, the diagnosis was made as a rare case of pancreatic paraganglioma on the basis of histological examination and immunohistochemistry.
副神经节瘤是一种罕见的神经内分泌肿瘤，起源于自主神经系统的肾上腺外嗜铬细胞，组织学上类似于化学感受器瘤。它们很罕见，在每200万人中约有1人受影响。这是一个适用于无论位于何处的副神经节肿瘤的通用术语。在罕见情况下，副神经节瘤出现在胰腺周围并累及胰腺，从而类似于任何一种更常见的原发性胰腺病变。胰腺副神经节瘤是一种极其罕见的肿瘤。它生长缓慢，因此建议进行根治性切除以实现治愈且预后良好。这些肿瘤不仅给临床医生和放射科医生，也给病理学家带来了相当大的诊断困难。在此，我们报告一例55岁女性病例，该患者左侧腹部肿胀3个月，最初临床怀疑为卵巢肿瘤。影像学检查显示胰腺尾部有一个病变，鉴别诊断为胰腺癌和转移性肿瘤。仅在剖腹探查后，根据组织学检查和免疫组化结果，诊断为罕见的胰腺副神经节瘤病例。
