West D C, Hampson I N, Arnold F, Kumar S
Science. 1985 Jun 14;228(4705):1324-6. doi: 10.1126/science.2408340.
Partial degradation products of sodium hyaluronate produced by the action of testicular hyaluronidase induced an angiogenic response (formation of new blood vessels) on the chick chorioallantoic membrane. Neither macromolecular hyaluronate nor exhaustively digested material had any angiogenic potential. Fractionation of the digestion products established that the activity was restricted to hyaluronate fragments between 4 and 25 disaccharides in length.
由睾丸透明质酸酶作用产生的透明质酸钠部分降解产物在鸡胚绒毛尿囊膜上诱导了血管生成反应（新血管形成）。大分子透明质酸和完全消化的物质均无血管生成潜力。对消化产物进行分级分离表明，活性仅限于长度为4至25个二糖的透明质酸片段。
