Tan Xiang, Wang Yongyong, Shi Lijun, Xian Lei, Guo Jianji, Liang Guanbiao, Chen Mingwu
1 Department of Cardiothoracic Surgery, First Affiliated Hospital, Guangxi Medical University , Nanning, China .
Genet Test Mol Biomarkers. 2014 Jan;18(1):50-6. doi: 10.1089/gtmb.2013.0296. Epub 2013 Oct 1.
The association between excision repair cross complementing group 2 (ERCC2) Asp312Asn polymorphism and lung cancer has been reported by many articles recently, but the results were controversial and inconclusive. Therefore, a meta-analysis was conducted to assess the relationship between them. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association. A total of 22 full studies with 20,101 subjects (8719 cases and 11,382 controls) were included in our research. The meta-analysis result showed that no significant association was found between ERCC2 Asp312Asn polymorphism and lung cancer in overall analysis (AA vs. GG, OR=1.023, 95% CI=0.824-1.270, p=0.838; AG vs. GG, OR=1.003, 95% CI=0.936-1.074, p=0.942; AA+AG vs. GG, OR=1.013, 95% CI=0.949-1.082, p=0.697; AA vs. AG+GG, OR=1.033, 95% CI=0.841-1.270, p=0.755). In subset analyses of stratified ethnicity, significantly increased risk was found among Asians (AA vs. GG, OR=3.212, 95% CI=1.518-6.795, p=0.002; AA vs. AG+GG, OR=3.174, 95% CI=1.500-6.712, p=0.003), whereas the association was not found among Caucasians under any genetic models. When analyses were conducted based on the study design, it indicated that the risk of lung cancer might be significantly increased in a hospital-based study (AA vs. GG, OR=1.323, 95% CI=1.096-1.596, p=0.004; AA+AG vs. GG, OR=1.109, 95% CI=1.000-1.229, p=0.050; AA vs. AG+GG, OR=1.285, 95% CI=1.076-1.535, p=0.006). In addition, a significantly increased risk for nonsmokers was detected under the dominant model (AA+AG vs. GG, OR=1.460, 95% CI=1.095-1.948, p=0.010). In conclusion, this meta-analysis suggested ERCC2 Asp312Asn polymorphism may increase the risk of lung cancer among Asians, whereas not among Caucasians.
近期许多文章报道了切除修复交叉互补基因2（ERCC2）Asp312Asn多态性与肺癌之间的关联，但结果存在争议且尚无定论。因此，进行了一项荟萃分析以评估二者之间的关系。采用合并比值比（OR）及95%置信区间（CI）来评估关联强度。本研究共纳入22项完整研究，涉及20101名受试者（8719例病例和11382例对照）。荟萃分析结果显示，总体分析中未发现ERCC2 Asp312Asn多态性与肺癌之间存在显著关联（AA与GG比较，OR = 1.023，95%CI = 0.824 - 1.270，p = 0.838；AG与GG比较，OR = 1.003，95%CI = 0.936 - 1.074，p = 0.942；AA + AG与GG比较，OR = 1.013，95%CI = 0.949 - 1.082，p = 0.697；AA与AG + GG比较，OR = 1.033，95%CI = 0.841 - 1.270，p = 0.755）。在按种族分层的亚组分析中，亚洲人群中发现风险显著增加（AA与GG比较，OR = 3.212，95%CI = 1.518 - 6.795，p = 0.002；AA与AG + GG比较，OR = 3.174，95%CI = 1.500 - 6.712，p = 0.003），而在任何遗传模型下，高加索人群中均未发现这种关联。基于研究设计进行分析时，结果表明在基于医院的研究中肺癌风险可能显著增加（AA与GG比较，OR = 1.323，95%CI = 1.096 - 1.596，p = 0.004；AA + AG与GG比较，OR = 1.109，95%CI = 1.000 - 1.229，p = 0.050；AA与AG + GG比较，OR = 1.285，95%CI = 1.076 - 1.535，p = 0.006）。此外，在显性模型下检测到非吸烟者的风险显著增加（AA + AG与GG比较，OR = 1.460，95%CI = 1.095 - 1.948，p = 0.010）。总之，这项荟萃分析表明，ERCC2 Asp312Asn多态性可能增加亚洲人群患肺癌的风险，而在高加索人群中则不然。
