硫酸葡聚糖对阿霉素（多柔比星）处理的小鼠存活时间和线粒体功能的影响。

Effect of dextran sulfate on the survival time and mitochondrial function of Adriamycin (doxorubicin)-treated mice.

作者信息

Shinozawa S, Fukuda T, Araki Y, Oda T

出版信息

Toxicol Appl Pharmacol. 1985 Jun 30;79(2):353-7. doi: 10.1016/0041-008x(85)90358-8.

Abstract

The effect of dextran sulfate on the survival time and mitochondrial function of adriamycin (ADM)-treated mice was studied. ADM-induced toxicity in mice was reduced by treatment with dextran sulfate (60, 100, 300, and 600 mg/kg, sc). The optimum dextran sulfate dose for protection against ADM-induced toxicity in mice was about 200 mg/kg/day (sc) and 100 mg/kg/day (po). Groups treated with dextran sulfate (300 mg/kg) had significantly improved mitochondrial function as measured by oxygen uptake of state 3 (p less than 0.01), dinitrophenol-altered respiration (p less than 0.01), and respiratory control index level (p less than 0.01). From these observations, it was concluded that ADM-induced toxicity due to reduced mitochondrial function can be ameliorated by the membrane stabilizing effect of dextran sulfate.

摘要

研究了硫酸葡聚糖对阿霉素（ADM）处理小鼠存活时间和线粒体功能的影响。用硫酸葡聚糖（60、100、300和600mg/kg，皮下注射）处理可降低ADM诱导的小鼠毒性。预防小鼠ADM诱导毒性的最佳硫酸葡聚糖剂量约为200mg/kg/天（皮下注射）和100mg/kg/天（口服）。用硫酸葡聚糖（300mg/kg）处理的组，通过状态3的氧摄取（p<0.01）、二硝基苯酚改变的呼吸（p<0.01）和呼吸控制指数水平（p<0.01）测量，线粒体功能有显著改善。从这些观察结果得出结论，硫酸葡聚糖的膜稳定作用可改善因线粒体功能降低导致的ADM诱导毒性。